{"doi":"10.1093/nar/gkae130","title":"COSA-1 mediated pro-crossover complex formation promotes meiotic crossing over in <i>C. elegans</i>","abstract":"Accurate chromosome segregation during meiosis requires the establishment of at least one crossover (CO) between each pair of homologous chromosomes. CO formation depends on a group of conserved pro-CO proteins, which colocalize at CO-designated sites during late meiotic prophase I. However, it remains unclear whether these pro-CO proteins form a functional complex and how they promote meiotic CO formation in vivo. Here, we show that COSA-1, a key component required for CO formation, interacts with other pro-CO factors, MSH-5 and ZHP-3, via its N-terminal disordered region. Point mutations that impair these interactions do not affect CO designation, but they strongly hinder the accumulation of COSA-1 at CO-designated sites and result in defective CO formation. These defects can be partially bypassed by artificially tethering an interaction-compromised COSA-1 derivate to ZHP-3. Furthermore, we revealed that the accumulation of COSA-1 into distinct foci is required to assemble functional 'recombination nodules'. These prevent early CO-designated recombination intermediates from being dismantled by the RTEL-1 helicase and protect late recombination intermediates, such as Holliday junctions, until they are resolved by CO-specific resolvases. Altogether, our findings provide insight into COSA-1 mediated pro-CO complex assembly and its contribution to CO formation.","journal":"Nucleic Acids Research","year":2024,"id":437894,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9494,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1247392,"name":"Nan Wang","orcid":"0000-0002-8055-047X","position":1,"is_corresponding":false},{"id":1247791,"name":"Guoteng Liu","orcid":null,"position":2,"is_corresponding":false},{"id":1247792,"name":"Wencong Nan","orcid":null,"position":3,"is_corresponding":false},{"id":686680,"name":"Bin Wang","orcid":"0000-0003-3352-6992","position":4,"is_corresponding":false},{"id":241989,"name":"Anton Gartner","orcid":"0000-0003-4639-9902","position":5,"is_corresponding":false},{"id":1182482,"name":"Hongtao Zhang","orcid":"0000-0003-4182-421X","position":6,"is_corresponding":false},{"id":1247393,"name":"Ye Hong","orcid":"0009-0005-7980-6414","position":7,"is_corresponding":false},{"id":1247391,"name":"Yuejun Yang","orcid":"0000-0002-2681-362X","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T02:00:34.490087Z","pmid":"38412290","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}