{"doi":"10.1093/nar/gkad1081","title":"Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF","abstract":"Several cancer core regulatory circuitries (CRCs) depend on the sustained generation of DNA accessibility by SWI/SNF chromatin remodelers. However, the window when SWI/SNF is acutely essential in these settings has not been identified. Here we used neuroblastoma (NB) cells to model and dissect the relationship between cell-cycle progression and SWI/SNF ATPase activity. We find that SWI/SNF inactivation impairs coordinated occupancy of non-pioneer CRC members at enhancers within 1 hour, rapidly breaking their autoregulation. By precisely timing inhibitor treatment following synchronization, we show that SWI/SNF is dispensable for survival in S and G2/M, but becomes acutely essential only during G1 phase. We furthermore developed a new approach to analyze the oscillating patterns of genome-wide DNA accessibility across the cell cycle, which revealed that SWI/SNF-dependent CRC binding sites are enriched at enhancers with peak accessibility during G1 phase, where they activate genes involved in cell-cycle progression. SWI/SNF inhibition strongly impairs G1-S transition and potentiates the ability of retinoids used clinically to induce cell-cycle exit. Similar cell-cycle effects in diverse SWI/SNF-addicted settings highlight G1-S transition as a common cause of SWI/SNF dependency. Our results illustrate that deeper knowledge of the temporal patterns of enhancer-related dependencies may aid the rational targeting of addicted cancers.","journal":"Nucleic Acids Research","year":2023,"id":337792,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9583,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":666459,"name":"Ling Tao","orcid":"0000-0002-4139-2894","position":1,"is_corresponding":false},{"id":1033363,"name":"Milan Dejmek","orcid":"0000-0002-8195-971X","position":2,"is_corresponding":false},{"id":356503,"name":"Michal Šála","orcid":"0000-0003-1554-6906","position":3,"is_corresponding":false},{"id":563259,"name":"Matthew D. Montierth","orcid":"0000-0002-0860-1420","position":4,"is_corresponding":false},{"id":640322,"name":"Yuen San Chan","orcid":"0000-0003-0467-7580","position":5,"is_corresponding":false},{"id":708065,"name":"Ivanshi Patel","orcid":null,"position":6,"is_corresponding":false},{"id":812354,"name":"Courtney Chambers","orcid":"0000-0002-2754-8282","position":7,"is_corresponding":false},{"id":636773,"name":"Mario Loeza Cabrera","orcid":"0000-0002-2397-7573","position":8,"is_corresponding":false},{"id":941368,"name":"Dane K. Hoffman","orcid":"0000-0002-3934-4770","position":9,"is_corresponding":false},{"id":504328,"name":"Ronald J. Parchem","orcid":"0000-0003-0038-2806","position":10,"is_corresponding":false},{"id":106810,"name":"Wenyi Wang","orcid":"0000-0003-0617-9438","position":11,"is_corresponding":false},{"id":356512,"name":"Radim Nencka","orcid":"0000-0001-6167-0380","position":12,"is_corresponding":false},{"id":666465,"name":"Eveline Barbieri","orcid":"0000-0003-4368-1451","position":13,"is_corresponding":false},{"id":463027,"name":"H. Courtney Hodges","orcid":"0000-0003-4441-497X","position":14,"is_corresponding":false},{"id":649817,"name":"Kateřina Čermáková","orcid":"0000-0003-3006-2213","position":0,"is_corresponding":true}],"reference_count":79,"raw_metadata":null,"created_at":"2026-07-19T01:10:31.133446Z","pmid":"37993417","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}