{"doi":"10.1093/nar/gkad066","title":"PARP1 associates with R-loops to promote their resolution and genome stability","abstract":"PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was also recently identified as a component of the R-loop-associated protein-protein interaction network, suggesting a potential role for PARP1 in resolving this structure. R-loops are three-stranded nucleic acid structures that consist of a RNA-DNA hybrid and a displaced non-template DNA strand. R-loops are involved in crucial physiological processes but can also be a source of genome instability if persistently unresolved. In this study, we demonstrate that PARP1 binds R-loops in vitro and associates with R-loop formation sites in cells which activates its ADP-ribosylation activity. Conversely, PARP1 inhibition or genetic depletion causes an accumulation of unresolved R-loops which promotes genomic instability. Our study reveals that PARP1 is a novel sensor for R-loops and highlights that PARP1 is a suppressor of R-loop-associated genomic instability.","journal":"Nucleic Acids Research","year":2023,"id":316850,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":90,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":310417,"name":"Parminder Kaur","orcid":"0000-0001-9183-4315","position":1,"is_corresponding":false},{"id":743423,"name":"Sofiane Y. Mersaoui","orcid":"0000-0001-6905-3600","position":2,"is_corresponding":false},{"id":895113,"name":"Daniela Muoio","orcid":"0000-0001-5732-5576","position":3,"is_corresponding":false},{"id":1021286,"name":"Zhiyan Silvia Liu","orcid":"0000-0001-5902-9375","position":4,"is_corresponding":false},{"id":1021287,"name":"Maxwell Bannister","orcid":"0000-0002-8528-2638","position":5,"is_corresponding":false},{"id":271006,"name":"Hai Dang Nguyen","orcid":"0000-0002-4200-8778","position":6,"is_corresponding":false},{"id":1021976,"name":"Caroline Curry","orcid":null,"position":7,"is_corresponding":false},{"id":232712,"name":"John M. Pascal","orcid":"0000-0002-2714-4317","position":8,"is_corresponding":false},{"id":263073,"name":"Guy G. Poirier","orcid":"0000-0002-4869-1424","position":9,"is_corresponding":false},{"id":237050,"name":"Hong Wang","orcid":"0000-0003-0165-3559","position":10,"is_corresponding":false},{"id":570092,"name":"Jean‐Yves Masson","orcid":"0000-0002-4403-7169","position":11,"is_corresponding":false},{"id":895114,"name":"Elise Fouquerel","orcid":"0000-0002-2542-2563","position":12,"is_corresponding":false},{"id":895608,"name":"Natalie Laspata","orcid":null,"position":0,"is_corresponding":true}],"reference_count":99,"raw_metadata":null,"created_at":"2026-07-19T01:06:44.698773Z","pmid":"36794853","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}