{"doi":"10.1093/nar/gkac883","title":"SIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>The SIGnaling Network Open Resource (SIGNOR 3.0, https://signor.uniroma2.it) is a public repository that captures causal information and represents it according to an ‘activity-flow’ model. SIGNOR provides freely-accessible static maps of causal interactions that can be tailored, pruned and refined to build dynamic and predictive models. Each signaling relationship is annotated with an effect (up/down-regulation) and with the mechanism (e.g. binding, phosphorylation, transcriptional activation, etc.) causing the regulation of the target entity. Since its latest release, SIGNOR has undergone a significant upgrade including: (i) a new website that offers an improved user experience and novel advanced search and graph tools; (ii) a significant content growth adding up to a total of approx. 33,000 manually-annotated causal relationships between more than 8900 biological entities; (iii) an increase in the number of manually annotated pathways, currently including pathways deregulated by SARS-CoV-2 infection or involved in neurodevelopment synaptic transmission and metabolism, among others; (iv) additional features such as new model to represent metabolic reactions and a new confidence score assigned to each interaction.</jats:p>","journal":"Nucleic Acids Research","year":2023,"id":588348,"datarank":3.4599258980130547,"base_score":5.153291594497779,"endowment":5.153291594497779,"self_citation_contribution":0.772993739174667,"citation_network_contribution":2.686932158838388,"self_endowment_contribution":0.772993739174667,"citer_contribution":2.686932158838388,"corpus_percentile":93.6,"corpus_rank":835,"citation_count":172,"citer_count":148,"citers_with_citation_signal":101,"citers_with_endowment":101,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":296062,"name":"Marta Iannuccelli","orcid":"0000-0002-2374-3531","position":1,"is_corresponding":false},{"id":1505181,"name":"Silvia Contino","orcid":null,"position":2,"is_corresponding":false},{"id":12281,"name":"Luisa Castagnoli","orcid":"0000-0001-5283-8671","position":3,"is_corresponding":false},{"id":296065,"name":"Luana Licata","orcid":"0000-0001-5084-9000","position":4,"is_corresponding":false},{"id":12283,"name":"Gianni Cesareni","orcid":"0000-0002-9528-6018","position":5,"is_corresponding":false},{"id":12455,"name":"Livia Perfetto","orcid":"0000-0003-4392-8725","position":6,"is_corresponding":false},{"id":1505180,"name":"Prisca Lo Surdo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"SIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>The SIGnaling Network Open Resource (SIGNOR 3.0, https://signor.uniroma2.it) is a public repository that captures causal information and represents it according to an ‘activity-flow’ model. 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