{"doi":"10.1093/nar/gkab971","title":"FlyAtlas 2 in 2022: enhancements to the <i>Drosophila melanogaster</i> expression atlas","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>FlyAtlas 2 (flyatlas2.org) is a database and web application for studying the expression of the genes of Drosophila melanogaster in different tissues of adults and larvae. It is based on RNA-Seq data, and incorporates both genes encoding proteins and microRNAs. We have now completed the population of the database with 13 tissues from both male and female adults, five sex-specific tissues, and eight larval tissues. Larval garland cell nephrocytes have also been included. Major enhancements have been made to the application. First, a facility has been added for a ‘Profile’ search for genes with a similar pattern of tissue expression as a query gene. This may help establish the function of genes for which this is currently unknown. Second, a facility has been added dedicated to the larval midgut, where the difference in gene expression in the five regions of different pH can be explored. A variety of further improvements to the interface are described.</jats:p>","journal":"Nucleic Acids Research","year":2022,"id":628755,"datarank":0.7278045395879427,"base_score":4.852030263919617,"endowment":4.852030263919617,"self_citation_contribution":0.7278045395879427,"citation_network_contribution":0.0,"self_endowment_contribution":0.7278045395879427,"citer_contribution":0.0,"corpus_percentile":72.7,"corpus_rank":3660,"citation_count":127,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1628053,"name":"Gayle Overend","orcid":"0000-0003-4033-1747","position":1,"is_corresponding":false},{"id":712710,"name":"Julian A. 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Larval garland cell nephrocytes have also been included. Major enhancements have been made to the application. First, a facility has been added for a ‘Profile’ search for genes with a similar pattern of tissue expression as a query gene. This may help establish the function of genes for which this is currently unknown. Second, a facility has been added dedicated to the larval midgut, where the difference in gene expression in the five regions of different pH can be explored. A variety of further improvements to the interface are described.</jats:p>","is_dataset_classified":null,"base_score":4.812184355372417,"endowment":4.812184355372417,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34718735","pmcid":"PMC8728208","openalex_id":"https://openalex.org/W3209622365","authors":[],"funders":[{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/K019953/1","title":"FlyAtlas2: a definitive, expanded NGS expression resource for the Drosophila community and beyond"},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/V011154/1","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/P024297/1","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/W002442/1","title":null}],"total_grants":4,"fwci":4.8848,"citation_percentile":0.96723945,"influential_citations":0,"citation_trend":[{"year":2021,"count":2},{"year":2022,"count":16},{"year":2023,"count":21},{"year":2024,"count":27},{"year":2025,"count":37},{"year":2026,"count":19}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1093/nar/gkab971","host_type":"journal"},{"url":"https://doi.org/10.1093/nar/gkab971","host_type":"publisher"},{"url":"https://academic.oup.com/nar/article-pdf/50/D1/D1010/42058638/gkab971.pdf","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34718735","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8728208","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8728208","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8728208?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1093/nar/gkab971","host_type":""},{"url":"https://eprints.gla.ac.uk/253937/1/253937.pdf","host_type":""},{"url":"https://dx.doi.org/10.1093/nar/gkab971","host_type":""}],"fields_of_study":["Insect Resistance and Genetics","Invertebrate Immune Response Mechanisms","Insect symbiosis and bacterial influences","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Databases, Genetic","Drosophila Proteins","Drosophila melanogaster","Female","Gene Expression Regulation","Larva","Male","MicroRNAs","Software"],"mesh_terms":["Animals","Drosophila melanogaster","Female","Gene Expression Regulation","Larva","Male","Software","Drosophila Proteins","Databases, Genetic","MicroRNAs"],"keywords":["Biology","Drosophila melanogaster","Gene","Gene expression","Larva","Genetics","Population","Drosophila (subgenus)","Melanogaster","microRNA","Computational biology","Database","Bioinformatics","Ecology","Male","MicroRNAs","Gene Expression Regulation","Databases, Genetic","Database Issue","Animals","Drosophila Proteins","Female","Software"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"bioproject"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T14:55:25.355947Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}