{"doi":"10.1093/nar/gkab538","title":"Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis","abstract":"A major stress response influenced by microRNAs (miRNAs) is senescence, a state of indefinite growth arrest triggered by sublethal cell damage. Here, through bioinformatic analysis and experimental validation, we identified miR-340-5p as a novel miRNA that foments cellular senescence. miR-340-5p was highly abundant in diverse senescence models, and miR-340-5p overexpression in proliferating cells rendered them senescent. Among the target mRNAs, miR-340-5p prominently reduced the levels of LBR mRNA, encoding lamin B receptor (LBR). Loss of LBR by ectopic overexpression of miR-340-5p derepressed heterochromatin in lamina-associated domains, promoting the expression of DNA repetitive elements characteristic of senescence. Importantly, overexpressing miR-340-5p enhanced cellular sensitivity to senolytic compounds, while antagonization of miR-340-5p reduced senescent cell markers and engendered resistance to senolytic-induced cell death. We propose that miR-340-5p can be exploited for removing senescent cells to restore tissue homeostasis and mitigate damage by senescent cells in pathologies of human aging.","journal":"Nucleic Acids Research","year":2021,"id":170145,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":254790,"name":"Carlos Anerillas","orcid":"0000-0003-4424-7913","position":1,"is_corresponding":false},{"id":300194,"name":"Sophia C Harris","orcid":null,"position":2,"is_corresponding":false},{"id":252579,"name":"Rachel Munk","orcid":null,"position":3,"is_corresponding":false},{"id":275718,"name":"Jennifer L. Martindale","orcid":"0000-0002-3234-6861","position":4,"is_corresponding":false},{"id":276701,"name":"Xiaoling Yang","orcid":null,"position":5,"is_corresponding":false},{"id":298507,"name":"Krystyna Mazan-Mamczarz","orcid":"0009-0005-1545-0500","position":6,"is_corresponding":false},{"id":451857,"name":"Yongqing Zhang","orcid":"0000-0003-0581-4882","position":7,"is_corresponding":false},{"id":228945,"name":"Indra Heckenbach","orcid":"0000-0001-7038-4677","position":8,"is_corresponding":false},{"id":228955,"name":"Morten Scheibye‐Knudsen","orcid":"0000-0002-6637-1280","position":9,"is_corresponding":false},{"id":275722,"name":"Supriyo De","orcid":"0000-0002-2075-7655","position":10,"is_corresponding":false},{"id":275721,"name":"Payel Sen","orcid":"0000-0003-2809-0901","position":11,"is_corresponding":false},{"id":249142,"name":"Kotb Abdelmohsen","orcid":"0000-0001-6240-5810","position":12,"is_corresponding":false},{"id":218108,"name":"Myriam Gorospe","orcid":"0000-0001-5439-3434","position":13,"is_corresponding":false},{"id":298506,"name":"Allison B. Herman","orcid":"0000-0003-3826-3247","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-18T23:46:19.728805Z","pmid":"34181735","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}