{"doi":"10.1093/nar/gkaa949","title":"Acetylation-modulated communication between the H3 N-terminal tail domain and the intrinsically disordered H1 C-terminal domain","abstract":"Linker histones (H1s) are key structural components of the chromatin of higher eukaryotes. However, the mechanisms by which the intrinsically disordered linker histone carboxy-terminal domain (H1 CTD) influences chromatin structure and gene regulation remain unclear. We previously demonstrated that the CTD of H1.0 undergoes a significant condensation (reduction of end-to-end distance) upon binding to nucleosomes, consistent with a transition to an ordered structure or ensemble of structures. Here, we show that deletion of the H3 N-terminal tail or the installation of acetylation mimics or bona fide acetylation within H3 N-terminal tail alters the condensation of the nucleosome-bound H1 CTD. Additionally, we present evidence that the H3 N-tail influences H1 CTD condensation through direct protein-protein interaction, rather than alterations in linker DNA trajectory. These results support an emerging hypothesis wherein the H1 CTD serves as a nexus for signaling in the nucleosome.","journal":"Nucleic Acids Research","year":2020,"id":76137,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":397287,"name":"Kevin J. Murphy","orcid":"0009-0006-9681-3285","position":1,"is_corresponding":false},{"id":240915,"name":"Tomoya Kujirai","orcid":"0000-0001-5547-9598","position":2,"is_corresponding":false},{"id":397288,"name":"Naoki Kamo","orcid":"0000-0002-5364-4454","position":3,"is_corresponding":false},{"id":398602,"name":"Junko Katô","orcid":null,"position":4,"is_corresponding":false},{"id":398603,"name":"Masako Koyama","orcid":null,"position":5,"is_corresponding":false},{"id":398604,"name":"Akimitsu Okamato","orcid":null,"position":6,"is_corresponding":false},{"id":397289,"name":"Gosuke Hayashi","orcid":"0000-0001-6853-2706","position":7,"is_corresponding":false},{"id":240923,"name":"Hitoshi Kurumizaka","orcid":"0000-0001-7412-3722","position":8,"is_corresponding":false},{"id":37098,"name":"Jeffrey J. Hayes","orcid":"0000-0001-6981-1803","position":9,"is_corresponding":false},{"id":397286,"name":"Fanfan Hao","orcid":"0000-0003-0272-9543","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T21:47:46.469293Z","pmid":"33125082","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}