{"doi":"10.1093/nar/gkaa777","title":"The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>The six major mammalian DNA repair pathways were discovered as independent processes, each dedicated to remove specific types of lesions, but the past two decades have brought into focus the significant interplay between these pathways. In particular, several studies have demonstrated that certain proteins of the nucleotide excision repair (NER) and base excision repair (BER) pathways work in a cooperative manner in the removal of oxidative lesions. This review focuses on recent data showing how the NER proteins, XPA, XPC, XPG, CSA, CSB and UV-DDB, work to stimulate known glycosylases involved in the removal of certain forms of base damage resulting from oxidative processes, and also discusses how some oxidative lesions are probably directly repaired through NER. Finally, since many glycosylases are inhibited from working on damage in the context of chromatin, we detail how we believe UV-DDB may be the first responder in altering the structure of damage containing-nucleosomes, allowing access to BER enzymes.</jats:p>","journal":"Nucleic Acids Research","year":2020,"id":45909,"datarank":2.5610177809040424,"base_score":4.770684624465665,"endowment":4.770684624465665,"self_citation_contribution":0.7156026936698499,"citation_network_contribution":1.8454150872341923,"self_endowment_contribution":0.7156026936698499,"citer_contribution":1.8454150872341923,"corpus_percentile":null,"corpus_rank":null,"citation_count":117,"citer_count":109,"citers_with_citation_signal":85,"citers_with_endowment":85,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":213683,"name":"Sripriya Raja","orcid":null,"position":1,"is_corresponding":false},{"id":182885,"name":"Bennett Van Houten","orcid":"0000-0002-4009-2478","position":2,"is_corresponding":false},{"id":213682,"name":"Namrata Kumar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.770684624465665,"endowment":4.770684624465665,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33010169","pmcid":"PMC7672477","openalex_id":"https://openalex.org/W3090573334","authors":[],"funders":[{"funder_name":"NIH","grant_id":"R01ES019566","title":null},{"funder_name":"NIH","grant_id":"R35ES031638","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R35ES031638-05","title":"Watching cooperative interactions between base and nucleotide excision repair proteins"},{"funder_name":"National Institutes of Health","grant_id":"5R01ES019566-08","title":"DNA damage recognition by nucleotide excision repair proteins"}],"total_grants":4,"fwci":5.8858,"citation_percentile":0.97336571,"influential_citations":9,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":23},{"year":2022,"count":25},{"year":2023,"count":22},{"year":2024,"count":15},{"year":2025,"count":13},{"year":2026,"count":18}],"oa_status":"gold","license":"CC BY NC","oa_locations":[{"url":"https://academic.oup.com/nar/article-pdf/48/20/11227/34368215/gkaa777.pdf","host_type":"journal"},{"url":"https://academic.oup.com/nar/article-pdf/48/20/11227/34368215/gkaa777.pdf","host_type":"GOLD"},{"url":"https://academic.oup.com/nar/article-pdf/48/20/11227/34368215/gkaa777.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/nar/article-pdf/48/20/11227/34368215/gkaa777.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/nar/gkaa777","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33010169","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7672477","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7672477","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7672477?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1093/nar/gkaa777","host_type":""},{"url":"https://dx.doi.org/10.1093/nar/gkaa777","host_type":""}],"fields_of_study":["DNA Repair Mechanisms","DNA and Nucleic Acid Chemistry","Advanced biosensing and bioanalysis techniques","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","5-Methylcytosine","DNA Damage","DNA Repair","DNA-Binding Proteins","Guanine","Humans","Oxidation-Reduction","Oxidative Stress","Thymine","Xeroderma Pigmentosum"],"mesh_terms":["DNA Damage","DNA Repair","DNA-Binding Proteins","Guanine","Humans","Oxidation-Reduction","Thymine","Xeroderma Pigmentosum","Oxidative Stress","5-Methylcytosine"],"keywords":["Nucleotide excision repair","Base excision repair","DNA glycosylase","Biology","DNA repair","DNA damage","Context (archaeology)","DNA","Oxidative damage","Oxidative phosphorylation","Chromatin","Xeroderma pigmentosum","Cell biology","Biochemistry","Genetics","Oxidative stress","Guanine","DNA-Binding Proteins","5-Methylcytosine","Humans","Survey and Summary","Oxidation-Reduction","Thymine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-04T19:14:26.599967Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}