{"doi":"10.1093/nar/gkaa768","title":"DIGGER: exploring the functional role of alternative splicing in protein interactions","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at https://exbio.wzw.tum.de/digger and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing.</jats:p>","journal":"Nucleic Acids 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Gress","orcid":null,"position":2,"is_corresponding":false},{"id":129504,"name":"Olga Tsoy","orcid":null,"position":3,"is_corresponding":false},{"id":129505,"name":"Olga V Kalinina","orcid":"0000-0002-9445-477X","position":4,"is_corresponding":false},{"id":17367,"name":"Jan Baumbach","orcid":"0000-0002-0282-0462","position":5,"is_corresponding":false},{"id":18658,"name":"Tim Kacprowski","orcid":"0000-0002-5393-2413","position":6,"is_corresponding":false},{"id":15023,"name":"Markus List","orcid":"0000-0002-0941-4168","position":7,"is_corresponding":false},{"id":129501,"name":"Zakaria 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