{"doi":"10.1093/nar/gkaa733","title":"Hedgehog signaling enables repair of ribosomal DNA double-strand breaks","abstract":"Ribosomal DNA (rDNA) consists of highly repeated sequences that are prone to incurring damage. Delays or failure of rDNA double-strand break (DSB) repair are deleterious, and can lead to rDNA transcriptional arrest, chromosomal translocations, genomic losses, and cell death. Here, we show that the zinc-finger transcription factor GLI1, a terminal effector of the Hedgehog (Hh) pathway, is required for the repair of rDNA DSBs. We found that GLI1 is activated in triple-negative breast cancer cells in response to ionizing radiation (IR) and localizes to rDNA sequences in response to both global DSBs generated by IR and site-specific DSBs in rDNA. Inhibiting GLI1 interferes with rDNA DSB repair and impacts RNA polymerase I activity and cell viability. Our findings tie Hh signaling to rDNA repair and this heretofore unknown function may be critically important in proliferating cancer cells.","journal":"Nucleic Acids Research","year":2020,"id":73306,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":385652,"name":"Victor T. G. Lin","orcid":"0000-0003-3311-1308","position":1,"is_corresponding":false},{"id":329562,"name":"Brandon J. Metge","orcid":"0000-0001-8615-2934","position":2,"is_corresponding":false},{"id":386642,"name":"Shannon E. Weeks","orcid":null,"position":3,"is_corresponding":false},{"id":385653,"name":"Dongquan Chen","orcid":"0000-0002-5006-5342","position":4,"is_corresponding":false},{"id":329565,"name":"Rajeev S. Samant","orcid":"0000-0001-5681-4976","position":5,"is_corresponding":false},{"id":329564,"name":"Lalita A. Shevde","orcid":"0000-0002-1520-1476","position":6,"is_corresponding":false},{"id":385651,"name":"Tshering Lama-Sherpa","orcid":"0000-0003-2057-1962","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-18T21:45:32.034078Z","pmid":"32894284","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}