{"doi":"10.1093/nar/gkaa199","title":"EXO1 resection at G-quadruplex structures facilitates resolution and replication","abstract":"G-quadruplexes represent unique roadblocks to DNA replication, which tends to stall at these secondary structures. Although G-quadruplexes can be found throughout the genome, telomeres, due to their G-richness, are particularly predisposed to forming these structures and thus represent difficult-to-replicate regions. Here, we demonstrate that exonuclease 1 (EXO1) plays a key role in the resolution of, and replication through, telomeric G-quadruplexes. When replication forks encounter G-quadruplexes, EXO1 resects the nascent DNA proximal to these structures to facilitate fork progression and faithful replication. In the absence of EXO1, forks accumulate at stabilized G-quadruplexes and ultimately collapse. These collapsed forks are preferentially repaired via error-prone end joining as depletion of EXO1 diverts repair away from error-free homology-dependent repair. Such aberrant repair leads to increased genomic instability, which is exacerbated at chromosome termini in the form of dysfunction and telomere loss.","journal":"Nucleic Acids Research","year":2020,"id":93675,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":467607,"name":"Kevin Kurtz","orcid":"0000-0002-4053-2138","position":1,"is_corresponding":false},{"id":467608,"name":"Kevin Lin","orcid":"0000-0003-2067-059X","position":2,"is_corresponding":false},{"id":468587,"name":"Sergey Karachenets","orcid":null,"position":3,"is_corresponding":false},{"id":52090,"name":"Chad L. Myers","orcid":"0000-0002-1026-5972","position":4,"is_corresponding":false},{"id":263507,"name":"Anja‐Katrin Bielinsky","orcid":"0000-0003-1783-619X","position":5,"is_corresponding":false},{"id":365949,"name":"Eric A. Hendrickson","orcid":"0000-0001-6734-6426","position":6,"is_corresponding":false},{"id":367723,"name":"Susanna Stroik","orcid":null,"position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T22:31:34.149524Z","pmid":"32232411","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}