{"doi":"10.1093/molbev/msu287","title":"Reassortment between Influenza B Lineages and the Emergence of a Coadapted PB1–PB2–HA Gene Complex","abstract":null,"journal":"Molecular Biology and Evolution","year":2015,"id":649854,"datarank":0.6952093482344455,"base_score":4.634728988229636,"endowment":4.634728988229636,"self_citation_contribution":0.6952093482344455,"citation_network_contribution":0.0,"self_endowment_contribution":0.6952093482344455,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":102,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":233050,"name":"Trevor Bedford","orcid":"0000-0002-4039-5794","position":1,"is_corresponding":false},{"id":499548,"name":"Samantha Lycett","orcid":"0000-0003-3159-596X","position":2,"is_corresponding":false},{"id":34991,"name":"Andrew Rambaut","orcid":"0000-0003-4337-3707","position":3,"is_corresponding":false},{"id":392259,"name":"Gytis Dudas","orcid":"0000-0002-0227-4158","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Reassortment between Influenza B Lineages and the Emergence of a Coadapted PB1–PB2–HA Gene Complex","abstract":"Influenza B viruses make a considerable contribution to morbidity attributed to seasonal influenza. Currently circulating influenza B isolates are known to belong to two antigenically distinct lineages referred to as B/Victoria and B/Yamagata. Frequent exchange of genomic segments of these two lineages has been noted in the past, but the observed patterns of reassortment have not been formalized in detail. We investigate interlineage reassortments by comparing phylogenetic trees across genomic segments. Our analyses indicate that of the eight segments of influenza B viruses only segments coding for polymerase basic 1 and 2 (PB1 and PB2) and hemagglutinin (HA) proteins have maintained separate Victoria and Yamagata lineages and that currently circulating strains possess PB1, PB2, and HA segments derived entirely from one or the other lineage; other segments have repeatedly reassorted between lineages thereby reducing genetic diversity. We argue that this difference between segments is due to selection against reassortant viruses with mixed-lineage PB1, PB2, and HA segments. Given sufficient time and continued recruitment to the reassortment-isolated PB1-PB2-HA gene complex, we expect influenza B viruses to eventually undergo sympatric speciation.","is_dataset_classified":null,"base_score":4.634728988229636,"endowment":4.634728988229636,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25323575","pmcid":"PMC4271528","openalex_id":"https://openalex.org/W2116003100","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"095831","title":null},{"funder_name":"Wellcome Trust","grant_id":"092807","title":null},{"funder_name":"European Research Council","grant_id":"260864","title":"Evolutionary reconstruction of viral spread in time and space"},{"funder_name":"Natural Environment Research Council","grant_id":"1086074","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BBS/E/D/20241864","title":null},{"funder_name":"European Commission","grant_id":"278433","title":"Preparedness, Prediction and Prevention of Emerging Zoonotic Viruses with Pandemic Potential using Multidisciplinary Approaches"}],"total_grants":6,"fwci":5.0892,"citation_percentile":0.9592617,"influential_citations":0,"citation_trend":[{"year":2015,"count":11},{"year":2016,"count":6},{"year":2017,"count":8},{"year":2018,"count":9},{"year":2019,"count":9},{"year":2020,"count":6},{"year":2021,"count":6},{"year":2022,"count":7},{"year":2023,"count":8},{"year":2024,"count":10},{"year":2025,"count":6},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://academic.oup.com/mbe/article-pdf/32/1/162/13170244/msu287.pdf","host_type":"journal"},{"url":"https://academic.oup.com/mbe/article-pdf/32/1/162/13170244/msu287.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/mbe/article-pdf/32/1/162/13170244/msu287.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/molbev/msu287","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25323575","host_type":"repository"},{"url":"https://www.research.ed.ac.uk/en/publications/e427d4c8-0ce1-4010-8c49-b802a1c60db6","host_type":"repository"},{"url":"https://eprints.gla.ac.uk/104805/","host_type":"journal"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4271528","host_type":"repository"},{"url":"https://hdl.handle.net/20.500.11820/e427d4c8-0ce1-4010-8c49-b802a1c60db6","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4271528","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4271528?pdf=render","host_type":"Europe_PMC"},{"url":"https://dx.doi.org/10.48550/arxiv.1403.1094","host_type":""},{"url":"http://dx.doi.org/10.1093/molbev/msu287","host_type":""},{"url":"http://arxiv.org/abs/1403.1094","host_type":""},{"url":"https://dx.doi.org/10.1093/molbev/msu287","host_type":""},{"url":"https://www.pure.ed.ac.uk/ws/files/17895359/Reassortment_between_Influenza_B_Lineages_and_the_Emergence_of_a_Coadapted_PB1_PB2_HA_Gene_Complex.pdf","host_type":""},{"url":"http://mbe.oxfordjournals.org/content/early/2014/10/30/molbev.msu287","host_type":""}],"fields_of_study":["Influenza Virus Research Studies","HIV Research and Treatment","Protein Structure and Dynamics","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Humans","Influenza, Human","Influenza B virus","Phylogeny","Selection, Genetic","Viral Proteins","Genome, Viral","Evolution, Molecular","Hemagglutinin Glycoproteins, Influenza Virus","Computational Biology","Genetic Speciation"],"keywords":["Biology","Reassortment","Gene","Genetics","Evolutionary biology","Coronavirus disease 2019 (COVID-19)","Evolution","Influenza","speciation","phylogenetics","Genetic Speciation","Populations and Evolution (q-bio.PE)","Computational Biology","Hemagglutinin Glycoproteins, Influenza Virus","Genome, Viral","Evolution, Molecular","Influenza B virus","Viral Proteins","FOS: Biological sciences","Influenza, Human","Humans","Selection, Genetic","Quantitative Biology - Populations and Evolution","Discoveries","Phylogeny"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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