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Second, gene deletions that alter the expression of dosage-sensitive genes are especially harmful. Third, by elevating the expression level of downregulated genes, we could experimentally mitigate the fitness defect of gene deletions. Our work shows that rewiring of genomic expression upon gene inactivation shapes the harmful effects of mutations.</jats:p>","journal":"Molecular Biology and Evolution","year":2021,"id":647938,"datarank":0.6078309065254932,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.16616505965052708,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.16616505965052708,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":14,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1688297,"name":"Zoltán Farkas","orcid":"0000-0002-5085-3306","position":1,"is_corresponding":false},{"id":350471,"name":"Djordje Bajić","orcid":"0000-0002-6716-7898","position":2,"is_corresponding":false},{"id":1688301,"name":"Dorottya Kalapis","orcid":null,"position":3,"is_corresponding":false},{"id":1688304,"name":"Andreea Daraba","orcid":null,"position":4,"is_corresponding":false},{"id":1688308,"name":"Karola Almási","orcid":null,"position":5,"is_corresponding":false},{"id":1198786,"name":"Bálint Kintses","orcid":"0000-0003-0844-0310","position":6,"is_corresponding":false},{"id":1688314,"name":"Zoltán Bódi","orcid":null,"position":7,"is_corresponding":false},{"id":1688318,"name":"Richard A Notebaart","orcid":null,"position":8,"is_corresponding":false},{"id":1688321,"name":"Juan F Poyatos","orcid":null,"position":9,"is_corresponding":false},{"id":91849,"name":"Patrick Kemmeren","orcid":"0000-0003-2237-7354","position":10,"is_corresponding":false},{"id":1688326,"name":"Frank C P Holstege","orcid":null,"position":11,"is_corresponding":false},{"id":1688328,"name":"Csaba Pál","orcid":null,"position":12,"is_corresponding":false},{"id":1285113,"name":"Balázs Papp","orcid":"0000-0003-3093-8852","position":13,"is_corresponding":false},{"id":1340042,"name":"Károly Kovács","orcid":"0000-0003-3796-4172","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Suboptimal Global Transcriptional Response Increases the Harmful Effects of Loss-of-Function Mutations","abstract":"<jats:title>Abstract</jats:title><jats:p>The fitness impact of loss-of-function mutations is generally assumed to reflect the loss of specific molecular functions associated with the perturbed gene. 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