{"doi":"10.1093/mmy/myad079","title":"Association of adverse effects with high serum posaconazole concentrations","abstract":"Posaconazole therapeutic drug monitoring (TDM) is widely utilized to assess therapeutic efficacy and safety; however, clinical effects of very high serum concentrations are unknown. A retrospective review of 90 patients receiving posaconazole for treatment or prophylaxis of invasive fungal infections with serum concentrations ≥3000 ng/mL from 1/1/2019 to 4/30/2021 evaluated the incidence and type of adverse drug reactions (ADRs). Symptomatic ADRs were very common in patients with posaconazole concentrations of ≥5000 ng/mL and 3000-4999 ng/mL (80% vs. 58.8%; P = 0.31). Posaconazole TDM should be performed for both treatment and prophylaxis indications and dose decrease for serum concentrations >3000 ng/mL should be considered.","journal":"Medical Mycology","year":2023,"id":358635,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9605,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":497258,"name":"Omar Abu Saleh","orcid":"0000-0003-4955-5544","position":1,"is_corresponding":false},{"id":894224,"name":"Supavit Chesdachai","orcid":"0000-0003-3507-6411","position":2,"is_corresponding":false},{"id":738292,"name":"Paul J. Jannetto","orcid":"0000-0002-5629-439X","position":3,"is_corresponding":false},{"id":275035,"name":"Kristin C. Mara","orcid":"0000-0002-8783-0191","position":4,"is_corresponding":false},{"id":705340,"name":"Zachary A. Yetmar","orcid":"0000-0003-2098-2868","position":5,"is_corresponding":false},{"id":1079715,"name":"Christina G. Rivera","orcid":"0000-0002-8308-3264","position":6,"is_corresponding":false},{"id":1109023,"name":"Kelsey Jensen","orcid":"0000-0001-8372-3316","position":0,"is_corresponding":true}],"reference_count":7,"raw_metadata":null,"created_at":"2026-07-19T01:13:48.379546Z","pmid":"37537152","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}