{"doi":"10.1093/jrsssc/qlaf010","title":"Correcting for bias due to mismeasured exposure in mediation analysis with a survival outcome","abstract":"We investigate the impact of exposure measurement error on assessing mediation with a survival outcome modelled by Cox regression. We first derive the bias formulas of natural indirect and direct effects with a rare outcome and no exposure-mediator interaction. We then develop several calibration approaches to correct for the measurement error-induced bias, and generalize our methods to accommodate a common outcome and an exposure-mediator interaction. We apply the proposed methods to analyse the Health Professionals Follow-up Study (1986-2016) and evaluate the extent to which reduced body mass index mediates the protective effect of physical activity on risk of cardiovascular diseases.","journal":"Journal of the Royal Statistical Society Series C (Applied Statistics)","year":2025,"id":562080,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9452,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":332379,"name":"Donna Spiegelman","orcid":"0000-0003-4006-4650","position":1,"is_corresponding":false},{"id":113688,"name":"Fan Li","orcid":"0000-0001-6183-1893","position":2,"is_corresponding":false},{"id":513421,"name":"Chao Cheng","orcid":"0000-0003-3234-5874","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T02:56:01.883848Z","pmid":"40837827","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}