{"doi":"10.1093/jpids/piaf053","title":"Increased Pro-inflammatory Biomarkers and Cardiovascular Risk in Young Adults Living With Perinatal HIV in Thailand","abstract":"BACKGROUND: We assessed levels of pro-inflammatory biomarkers as possible surrogate markers of cardiovascular disease (CVD) risk in Thai young adults with perinatally acquired HIV infection (YA-PHIV). METHODS: Serum samples and baseline data from YA-PHIV enrolled in a prospective cohort study from November 2020 to July 2021 at five tertiary care hospitals in Thailand were analyzed. We measured high-sensitivity C-reactive protein (hs-CRP), soluble CD163 (sCD163), and interleukin (IL)-18 levels. Data were analyzed using nonparametric methods. RESULTS: Among 347 YA-PHIV, 54% were female, the mean age was 21.7 ± 2.0 years, the median duration of antiretroviral treatment was 16.7 years (IQR 13.4-18.4), and 72 (21%) had virologic failure (HIV viral load >1000 copies/mL). The hs-CRP levels were <1.0 mg/L (low CVD risk) in 170 (49%), between 1.0-<3.0 (indicating intermediate CVD risk) in 88 (25%), and ≥3 mg/L (indicating high CVD risk) in 89 (26%). The median IL-18 level was 82.2 pg/mL (IQR 33.9-151.7), and sCD163 was 53.6 ng/mL (IQR 31.1-90.1). YA-PHIV with virologic failure had a significantly higher level for all three biomarker levels than those with virologic suppression. Increasing age was associated with hs-CRP >3 mg/L; males were more likely to have high levels of IL-18; no factors were associated with sCD163 level. CONCLUSIONS: Increased pro-inflammatory biomarkers in YA-PHIV support the presence of ongoing inflammation, particularly in those with virologic failure. HIV care for YA-PHIV should focus on virologic control and modifiable metabolic risk factors. Active monitoring for cardiovascular manifestations in YA-PHIV risk is warranted as they age.","journal":"Journal of the Pediatric Infectious Diseases Society","year":2025,"id":587003,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":398172,"name":"Kulkanya Chokephaibulkit","orcid":"0000-0002-0140-4600","position":1,"is_corresponding":false},{"id":1081978,"name":"Wipaporn Natalie Songtaweesin","orcid":"0000-0003-3440-732X","position":2,"is_corresponding":false},{"id":374396,"name":"Pradthana Ounchanum","orcid":"0009-0007-9005-2697","position":3,"is_corresponding":false},{"id":374397,"name":"Pope Kosalaraksa","orcid":"0000-0003-4450-2398","position":4,"is_corresponding":false},{"id":380558,"name":"Tavitiya Sudjaritruk","orcid":"0000-0002-3686-4623","position":5,"is_corresponding":false},{"id":967765,"name":"Supattra Rungmaitree","orcid":"0000-0001-9439-9152","position":6,"is_corresponding":false},{"id":607912,"name":"Surinda Kawichai","orcid":"0000-0003-0189-4125","position":7,"is_corresponding":false},{"id":438559,"name":"Pagakrong Lumbiganon","orcid":null,"position":8,"is_corresponding":false},{"id":374399,"name":"Tulathip Suwanlerk","orcid":"0000-0001-5801-0760","position":9,"is_corresponding":false},{"id":164023,"name":"Thanyawee Puthanakit","orcid":null,"position":10,"is_corresponding":false},{"id":1502489,"name":"Thai PAPAYA study team","orcid":null,"position":11,"is_corresponding":false},{"id":374392,"name":"Linda Aurpibul","orcid":"0000-0003-0246-8187","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T02:59:36.020030Z","pmid":"41432991","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}