{"doi":"10.1093/jpids/piab081","title":"Antigen Test Performance Among Children and Adults at a SARS-CoV-2 Community Testing Site","abstract":"BACKGROUND: Performance characteristics of SARS-CoV-2 antigen tests among children are limited despite the need for point-of-care testing in school and childcare settings. We describe children seeking SARS-CoV-2 testing at a community site and compare antigen test performance to real-time reverse transcription-polymerase chain reaction (RT-PCR) and viral culture. METHODS: Two anterior nasal specimens were self-collected for BinaxNOW antigen and RT-PCR testing, along with demographics, symptoms, and exposure information from individuals ≥5 years at a community testing site. Viral culture was attempted on residual antigen or RT-PCR-positive specimens. Demographic and clinical characteristics, and the performance of SARS-CoV-2 antigen tests, were compared among children (<18 years) and adults. RESULTS: About 1 in 10 included specimens were from children (225/2110); 16.4% (37/225) were RT-PCR-positive. Cycle threshold values were similar among RT-PCR-positive specimens from children and adults (22.5 vs 21.3, P = .46) and among specimens from symptomatic and asymptomatic children (22.5 vs 23.2, P = .39). Sensitivity of antigen test compared to RT-PCR was 73.0% (27/37) among specimens from children and 80.8% (240/297) among specimens from adults; among specimens from children, specificity was 100% (188/188), positive and negative predictive values were 100% (27/27) and 94.9% (188/198), respectively. Virus was isolated from 51.4% (19/37) of RT-PCR-positive pediatric specimens; all 19 had positive antigen test results. CONCLUSIONS: With lower sensitivity relative to RT-PCR, antigen tests may not diagnose all positive COVID-19 cases; however, antigen testing identified children with live SARS-CoV-2 virus.","journal":"Journal of the Pediatric Infectious Diseases Society","year":2021,"id":178723,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9312,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":460402,"name":"Melissa Whaley","orcid":null,"position":1,"is_corresponding":false},{"id":230975,"name":"Melisa M. Shah","orcid":"0000-0002-7277-1547","position":2,"is_corresponding":false},{"id":499747,"name":"Phillip P. Salvatore","orcid":"0000-0001-8305-9056","position":3,"is_corresponding":false},{"id":724692,"name":"Hannah E. Segaloff","orcid":"0000-0003-4716-7468","position":4,"is_corresponding":false},{"id":724693,"name":"Augustina Delaney","orcid":"0000-0003-2627-7756","position":5,"is_corresponding":false},{"id":687965,"name":"Dustin W. Currie","orcid":"0000-0003-2061-2672","position":6,"is_corresponding":false},{"id":725236,"name":"Lauren Boyle-Estheimer","orcid":null,"position":7,"is_corresponding":false},{"id":650573,"name":"Michelle O’Hegarty","orcid":null,"position":8,"is_corresponding":false},{"id":724694,"name":"Clint N. Morgan","orcid":"0000-0001-8646-8920","position":9,"is_corresponding":false},{"id":379282,"name":"Jennifer K. Meece","orcid":"0000-0002-6486-3505","position":10,"is_corresponding":false},{"id":725237,"name":"Lynn Ivacic","orcid":null,"position":11,"is_corresponding":false},{"id":225078,"name":"Natalie J. Thornburg","orcid":"0000-0003-3523-3616","position":12,"is_corresponding":false},{"id":225064,"name":"Azaibi Tamin","orcid":"0000-0001-9726-8940","position":13,"is_corresponding":false},{"id":225063,"name":"Jennifer L. 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Tate","orcid":"0000-0002-8114-6196","position":24,"is_corresponding":false},{"id":383138,"name":"Christopher H. Hsu","orcid":"0000-0003-4681-9516","position":25,"is_corresponding":false},{"id":539692,"name":"Hannah L. Kirking","orcid":"0000-0003-2662-3110","position":26,"is_corresponding":false},{"id":724691,"name":"Laura Ford","orcid":"0000-0002-6253-9672","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:47:40.592580Z","pmid":"34468732","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}