{"doi":"10.1093/jnen/nlaf150","title":"Clinicopathological study of chronic traumatic encephalopathy pathology in a population-based cohort","abstract":"Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease linked to repetitive traumatic brain injury, but its prevalence and risk factors in the general population remain poorly defined. We investigated CTE neuropathological changes (CTE-NC) in an admixed, population-based clinicopathological cohort. Neuropathological evaluation was conducted on brain samples from 1151 individuals in the University of São Paulo Biobank for Aging Studies collected from 2004 to 2022. CTE-NC and aging-related tau astrogliopathy (ARTAG) were assessed across 14 963 histological slides using p-tau immunostaining. Clinical, cognitive, and neuropsychiatric data were obtained via informant interviews; information on sports exposure and traumatic brain injury history was limited. Seven cases (0.6%) met criteria for CTE-NC, mean age at death 73.4 ± 12.5 years; 1 was female. Dementia was present in 43% of CTE-NC cases; 57% exhibited neuropsychiatric symptoms. Most common co-pathologies were Alzheimer disease-type changes, ARTAG, and argyrophilic grain disease. Comprehensive exposure histories were unavailable for most cases; 2 had documented soccer involvement. These findings indicate that CTE-NC is rare in this population-based Brazilian cohort and predominantly affects males with frequent coexisting neuropathologies. Findings align with reports from high-income countries and support prioritizing primary prevention by reducing exposure to repetitive head impacts in sport and other settings.","journal":"Journal of Neuropathology & Experimental Neurology","year":2025,"id":587815,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10062,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1504006,"name":"Christopher Nowinski","orcid":null,"position":1,"is_corresponding":false},{"id":226634,"name":"Cláudia Kimie Suemoto","orcid":"0000-0002-5942-4778","position":2,"is_corresponding":false},{"id":1504007,"name":"Renata Elaine P Leite","orcid":null,"position":3,"is_corresponding":false},{"id":1504008,"name":"Renata Eloah de Lucena Ferretti-Rebustini","orcid":null,"position":4,"is_corresponding":false},{"id":1504009,"name":"Wilson Jacob-Filho","orcid":null,"position":5,"is_corresponding":false},{"id":413866,"name":"Carlos Augusto Pasqualucci","orcid":"0000-0001-6608-2473","position":6,"is_corresponding":false},{"id":1504010,"name":"Ricardo Nitrini","orcid":null,"position":7,"is_corresponding":false},{"id":1504011,"name":"Lea T Grinberg","orcid":null,"position":8,"is_corresponding":false},{"id":262262,"name":"Roberta Diehl Rodriguez","orcid":"0000-0002-6544-7861","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T02:59:39.958043Z","pmid":"41627284","pmcid":"PMC13127888","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}