{"doi":"10.1093/jnen/nlaf022","title":"Expanding the spectrum of <i>TERT</i> promoter mutations in CNS tumors: A case series of non-canonical mutations","abstract":"To the Editor: TERT promoter (TERTp) mutations are a molecular biomarker in multiple central nervous system (CNS) tumor types and are primarily represented by the canonical C228T and C250T activating hotspot missense mutations.1 These canonical mutations generate a new consensus sequence for binding of E26 transformation-specific (ETS) and recruit transcription factor complex GA-binding protein, increasing TERT expression and contributing to telomere maintenance.2 Other clinically relevant TERTp sequence variants with evidence of cancer association and functional experimental data supporting oncogenicity have been reported and are hereafter referred to as “non-canonical TERTp mutations”.3 Examples of non-canonical TERTp mutations include the c.-57A>C mutation exclusively described in non-CNS tumors and the TERTp activating duplications recurrently reported in glioblastoma, IDH-wildtype (GBM).3–5 Herein, we describe the clinicopathological, molecular, and epigenetic characterization of a series of 12 CNS tumors (11 gliomas and 1 meningioma) harboring previously reported and potentially novel non-canonical TERTp mutations, expanding the spectrum of TERTp mutations associated with primary CNS tumors.","journal":"Journal of Neuropathology & Experimental Neurology","year":2025,"id":563179,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9657,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":442017,"name":"Jorge Trejo‐Lopez","orcid":"0000-0001-5346-7753","position":1,"is_corresponding":false},{"id":251186,"name":"Beth A. 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Vaubel","orcid":"0000-0001-8842-5975","position":20,"is_corresponding":false},{"id":475043,"name":"Aditya Raghunathan","orcid":"0000-0001-6198-7441","position":21,"is_corresponding":false},{"id":226432,"name":"Caterina Giannini","orcid":"0000-0003-2757-6782","position":22,"is_corresponding":false},{"id":226434,"name":"Robert B. Jenkins","orcid":"0000-0002-4049-694X","position":23,"is_corresponding":false},{"id":692889,"name":"Cristiane M. 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