{"doi":"10.1093/jnen/nlac068","title":"Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository","abstract":"The Essential Tremor Centralized Brain Repository is the largest repository of prospectively collected essential tremor (ET) brains (n = 231). Hence, we are uniquely poised to address several questions: What proportion of ET cases has Lewy pathology (LP)? What is the nature of that pathology and how does it relate to other comorbidities? Each brain had a complete neuropathological assessment, including α-synuclein immunostaining. We created a 10-category classification scheme to fully encapsulate the patterns of LP observed. Four metrics of cerebellar pathology were also quantified. Mean age at death = 89.0 ± 6.4 years. Fifty-eight (25.1%) had LP and 46 (19.9%) had early to late stages of Parkinson disease (PD). LP was very heterogeneous. Of 58 cases with LP, 14 (24.1%) clinically developed possible PD or PD after a latency of 5 or more years. There was a similar degree of cerebellar pathology in ET cases both with and without LP. In summary, 1 in 4 ET cases had LP-a proportion that seems higher than expected based on studies among control populations. Heterogeneous LP likely reflects clinical associations between ET and PD, and ET with Alzheimer disease-type neuropathology. These data further our understanding of ET and its relatedness to other degenerative diseases.","journal":"Journal of Neuropathology & Experimental Neurology","year":2022,"id":243144,"datarank":1.1665773024584558,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.6290494616900394,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.6290494616900394,"corpus_percentile":82.43211882107218,"corpus_rank":2272,"citation_count":35,"citer_count":22,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.9258,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":585654,"name":"Daniella Iglesias Hernandez","orcid":"0000-0001-8407-0230","position":1,"is_corresponding":false},{"id":585655,"name":"Nora Hernández","orcid":"0000-0001-7038-1492","position":2,"is_corresponding":false},{"id":585093,"name":"Xena Flowers","orcid":null,"position":3,"is_corresponding":false},{"id":255403,"name":"Sheng‐Han Kuo","orcid":"0000-0002-9412-931X","position":4,"is_corresponding":false},{"id":7428,"name":"Jean Paul Vonsattel","orcid":null,"position":5,"is_corresponding":false},{"id":255402,"name":"Phyllis L. Faust","orcid":"0000-0001-6533-7921","position":6,"is_corresponding":false},{"id":255401,"name":"Elan D. Louis","orcid":"0000-0003-2062-362X","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T00:23:16.032700Z","pmid":"35950950","pmcid":"PMC9487643","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}