{"doi":"10.1093/jncics/pkae097","title":"Characterization of undifferentiated carcinomas of the pancreas with and without osteoclast-like giant cells","abstract":"BACKGROUND: Undifferentiated carcinoma (UC) is a rare subtype of pancreatic cancer distinguished from UC with osteoclast-like giant cells (UC-OGC) in 2019, affecting interpretation of literature that does not distinguish these subtypes. We sought to identify translationally relevant differences between these 2 variants and compared with pancreatic ductal adenocarcinoma. METHODS: We characterized clinical and multiomic differences between UC (n = 32) and UC-OGC (n = 15) using DNA sequencing, RNA sequencing, and multiplex immunofluorescence and compared these findings with pancreatic ductal adenocarcinoma. RESULTS: Characteristics at diagnosis were similar between UC and UC-OGC, though the latter was more resectable (P = .009). Across all stages, median overall survival was shorter for UC than for UC-OGC (0.4 years vs 10.8 years, respectively; P = .003). This shorter survival was retained after stratification by resection, albeit without statistical significance (1.8 years vs 11.9 years, respectively; P = .08). In a subset of patients with available tissue, the genomic landscape was similar among UC (n = 9), UC-OGC (n = 5), and pancreatic ductal adenocarcinoma (n = 159). Bulk RNA sequencing was deconvoluted and, along with multiplex immunofluorescence in UC (n = 13), UC-OGC (n = 5), and pancreatic ductal adenocarcinoma (n = 16), demonstrated statistically significantly increased antigen-presenting cells, including M2 macrophages and natural killer cells, and decreased cytotoxic and regulatory T cells in UC and UC-OGC vs pancreatic ductal adenocarcinoma. Findings were similar between UC and UC-OGC , except for decreased regulatory T cells in UC-OGC (P = .04). CONCLUSIONS: In this series, UC was more aggressive than UC-OGC, with these variants having more antigen-presenting cells and fewer regulatory T cells than pancreatic ductal adenocarcinoma, suggesting potential for immune-modulating therapies in the treatment of these pancreatic cancer subtypes.","journal":"JNCI Cancer Spectrum","year":2024,"id":472074,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7294,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":225399,"name":"Valerie Gunchick","orcid":"0000-0002-9392-0644","position":1,"is_corresponding":false},{"id":915504,"name":"Jake McGue","orcid":"0000-0001-6131-7798","position":2,"is_corresponding":false},{"id":728522,"name":"Zhaoping Qin","orcid":"0000-0003-2439-5417","position":3,"is_corresponding":false},{"id":51858,"name":"Chandan Kumar‐Sinha","orcid":"0000-0002-8696-3400","position":4,"is_corresponding":false},{"id":225420,"name":"Filip Bednar","orcid":"0000-0001-5193-9817","position":5,"is_corresponding":false},{"id":886229,"name":"Noah A. Brown","orcid":"0000-0001-9151-5912","position":6,"is_corresponding":false},{"id":88874,"name":"Jiaqi Shi","orcid":"0000-0003-4893-1587","position":7,"is_corresponding":false},{"id":582192,"name":"Aaron M. Udager","orcid":"0000-0002-8254-5404","position":8,"is_corresponding":false},{"id":225421,"name":"Timothy L. Frankel","orcid":"0000-0001-5987-0404","position":9,"is_corresponding":false},{"id":840227,"name":"Mark M. Zalupski","orcid":"0000-0002-2114-9352","position":10,"is_corresponding":false},{"id":225417,"name":"Vaibhav Sahai","orcid":"0000-0003-1892-1548","position":11,"is_corresponding":false},{"id":1307647,"name":"Jamie N. Mills","orcid":null,"position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T02:05:53.032464Z","pmid":"39363498","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}