{"doi":"10.1093/jncics/pkae042","title":"Effects of vitamin D supplementation on a deep learning–based mammographic evaluation in SWOG S0812","abstract":"Deep learning-based mammographic evaluations could noninvasively assess response to breast cancer chemoprevention. We evaluated change in a convolutional neural network-based breast cancer risk model applied to mammograms among women enrolled in SWOG S0812, which randomly assigned 208 premenopausal high-risk women to receive oral vitamin D3 20 000 IU weekly or placebo for 12 months. We applied the convolutional neural network model to mammograms collected at baseline (n = 109), 12 months (n = 97), and 24 months (n = 67) and compared changes in convolutional neural network-based risk score between treatment groups. Change in convolutional neural network-based risk score was not statistically significantly different between vitamin D and placebo groups at 12 months (0.005 vs 0.002, P = .875) or at 24 months (0.020 vs 0.001, P = .563). The findings are consistent with the primary analysis of S0812, which did not demonstrate statistically significant changes in mammographic density with vitamin D supplementation compared with placebo. There is an ongoing need to evaluate biomarkers of response to novel breast cancer chemopreventive agents.","journal":"JNCI Cancer Spectrum","year":2024,"id":475169,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":243116,"name":"Garnet L. Anderson","orcid":"0000-0001-5087-7837","position":1,"is_corresponding":false},{"id":504625,"name":"Simukayi Mutasa","orcid":"0000-0002-6366-7481","position":2,"is_corresponding":false},{"id":107125,"name":"Dawn L. Hershman","orcid":"0000-0001-8807-153X","position":3,"is_corresponding":false},{"id":251556,"name":"Mary Beth Terry","orcid":"0000-0002-4106-5033","position":4,"is_corresponding":false},{"id":251558,"name":"Parisa Tehranifar","orcid":"0000-0002-0605-3934","position":5,"is_corresponding":false},{"id":553024,"name":"Danika L. Lew","orcid":null,"position":6,"is_corresponding":false},{"id":1312321,"name":"Monica Yee","orcid":null,"position":7,"is_corresponding":false},{"id":193400,"name":"Eric Brown","orcid":"0009-0003-2540-5581","position":8,"is_corresponding":false},{"id":1312322,"name":"Sebastien S. Kairouz","orcid":null,"position":9,"is_corresponding":false},{"id":1312323,"name":"Nafisa Kuwajerwala","orcid":null,"position":10,"is_corresponding":false},{"id":288246,"name":"Therese B. Bevers","orcid":"0000-0001-6006-3108","position":11,"is_corresponding":false},{"id":1312324,"name":"John E. Doster","orcid":null,"position":12,"is_corresponding":false},{"id":1312325,"name":"Corrine Zarwan","orcid":null,"position":13,"is_corresponding":false},{"id":461452,"name":"Laura Kruper","orcid":"0000-0002-7268-0354","position":14,"is_corresponding":false},{"id":283272,"name":"Lori M. Minasian","orcid":null,"position":15,"is_corresponding":false},{"id":432428,"name":"Leslie G. Ford","orcid":"0000-0003-2412-8028","position":16,"is_corresponding":false},{"id":225491,"name":"Banu Arun","orcid":"0000-0002-5475-8509","position":17,"is_corresponding":false},{"id":27761,"name":"Marian L. Neuhouser","orcid":"0000-0002-3876-0000","position":18,"is_corresponding":false},{"id":251841,"name":"Gary E. Goodman","orcid":"0009-0008-0097-8582","position":19,"is_corresponding":false},{"id":292790,"name":"Powel H. Brown","orcid":"0000-0002-3398-163X","position":20,"is_corresponding":false},{"id":407027,"name":"Richard Ha","orcid":"0000-0003-1704-2875","position":21,"is_corresponding":false},{"id":497241,"name":"Katherine D. Crew","orcid":"0000-0002-9637-2962","position":22,"is_corresponding":false},{"id":574811,"name":"Julia E. McGuinness","orcid":"0000-0001-5292-1440","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T02:06:16.992586Z","pmid":"38814817","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}