{"doi":"10.1093/jncics/pkad093","title":"A phase II clinical trial of frameless, fractionated stereotactic radiation therapy for brain metastases","abstract":"Stereotactic radiation therapy yields high rates of local control for brain metastases, but patients in rural or suburban areas face geographic and socioeconomic barriers to its access. We conducted a phase II clinical trial of frameless, fractionated stereotactic radiation therapy for brain metastases in an integrated academic satellite network for patients 18 years of age or older with 4 or fewer brain metastases. Dose was based on gross tumor volume: less than 3.0 cm, 27 Gy in 3 fractions and 3.0 to 3.9 cm, 30 Gy in 5 fractions. Median follow-up was 10 months for 73 evaluable patients, with a median age of 68 years. Median intracranial progression-free survival was 7.1 months (95% confidence interval = 5.3 to not reached), and median survival was 7.2 months (95% confidence interval = 5.4 to not reached); there were no serious adverse events. Outcomes of this trial compare favorably with contemporary trials, and this treatment strategy provides opportunities to expand stereotactic radiation therapy access to underserved populations.","journal":"JNCI Cancer Spectrum","year":2023,"id":387003,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":435754,"name":"Mike Hernández","orcid":"0000-0002-5074-5460","position":1,"is_corresponding":false},{"id":1156262,"name":"Pamela J. Schlembach","orcid":null,"position":2,"is_corresponding":false},{"id":1156263,"name":"John Bowers","orcid":null,"position":3,"is_corresponding":false},{"id":500801,"name":"Mary Frances McAleer","orcid":"0000-0003-0585-1712","position":4,"is_corresponding":false},{"id":259416,"name":"Paul D. Brown","orcid":"0000-0003-0022-4533","position":5,"is_corresponding":false},{"id":1156264,"name":"Ramesh Gopal","orcid":null,"position":6,"is_corresponding":false},{"id":183635,"name":"Lee Wiederhold","orcid":null,"position":7,"is_corresponding":false},{"id":1156265,"name":"Todd A. Swanson","orcid":null,"position":8,"is_corresponding":false},{"id":576365,"name":"Shalin Shah","orcid":"0000-0002-1622-8443","position":9,"is_corresponding":false},{"id":1155840,"name":"Jing Li","orcid":"0000-0003-3654-9831","position":10,"is_corresponding":false},{"id":401724,"name":"Sherise D. Ferguson","orcid":"0000-0002-6344-0615","position":11,"is_corresponding":false},{"id":1156266,"name":"Nancy V Philip","orcid":null,"position":12,"is_corresponding":false},{"id":1156267,"name":"Lilybeth DeGracia","orcid":null,"position":13,"is_corresponding":false},{"id":501928,"name":"Elizabeth S. Bloom","orcid":null,"position":14,"is_corresponding":false},{"id":244405,"name":"Stephen G. Chun","orcid":"0000-0002-4324-8044","position":15,"is_corresponding":false},{"id":1142188,"name":"Amit Garg","orcid":"0000-0001-7952-0671","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T01:18:04.706547Z","pmid":"37944053","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}