{"doi":"10.1093/jncics/pkac035","title":"The Impact of Androgen Deprivation Therapy on COVID-19 Illness in Men With Prostate Cancer","abstract":"BACKGROUND: TMPRSS2, a cell surface protease regulated by androgens and commonly upregulated in prostate cancer (PCa), is a necessary component for SARS-CoV-2 viral entry into respiratory epithelial cells. Previous reports suggested a lower risk of SARS-CoV-2 among PCa patients on androgen deprivation therapy (ADT). However, the impact of ADT on severe COVID-19 illness is poorly understood. METHODS: We performed a multicenter study across 7 US medical centers and evaluated patients with PCa and SARS-CoV-2 detected by polymerase-chain-reaction between March 1, 2020, and May 31, 2020. PCa patients were considered on ADT if they had received appropriate ADT treatment within 6 months of COVID-19 diagnosis. We used multivariable logistic and Cox proportional-hazard regression models for analysis. All statistical tests were 2-sided. RESULTS: We identified 465 PCa patients (median age = 71 years) with a median follow-up of 60 days. Age, body mass index, cardiovascular comorbidity, and PCa clinical disease state adjusted overall survival (hazard ratio [HR] = 1.16, 95% confidence interval [CI] = 0.68 to 1.98, P = .59), hospitalization status (HR = 0.96, 95% CI = 0.52 to 1.77, P = .90), supplemental oxygenation (HR 1.14, 95% CI = 0.66 to 1.99, P = .64), and use of mechanical ventilation (HR = 0.81, 95% CI = 0.25 to 2.66, P = .73) were similar between ADT and non-ADT cohorts. Similarly, the addition of androgen receptor-directed therapy within 30 days of COVID-19 diagnosis to ADT vs ADT alone did not statistically significantly affect overall survival (androgen receptor-directed therapy: HR = 1.27, 95% CI = 0.69 to 2.32, P = .44). CONCLUSIONS: In this retrospective cohort of PCa patients, the use of ADT was not demonstrated to influence severe COVID-19 outcomes, as defined by hospitalization, supplemental oxygen use, or death. Age 70 years and older was statistically significantly associated with a higher risk of developing severe COVID-19 disease.","journal":"JNCI Cancer Spectrum","year":2022,"id":272796,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9308,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":711412,"name":"Vaibhav G. 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Wise","orcid":"0000-0003-3419-4723","position":8,"is_corresponding":false},{"id":266850,"name":"Qian Qin","orcid":"0000-0003-0653-8920","position":9,"is_corresponding":false},{"id":939353,"name":"George Mellgard","orcid":"0000-0002-8649-9855","position":10,"is_corresponding":false},{"id":369652,"name":"Himanshu Joshi","orcid":"0000-0003-0272-0733","position":11,"is_corresponding":false},{"id":744557,"name":"Jones T. Nauseef","orcid":"0000-0003-2302-4171","position":12,"is_corresponding":false},{"id":939354,"name":"David A. Green","orcid":"0000-0003-3189-9998","position":13,"is_corresponding":false},{"id":553766,"name":"Panagiotis J. Vlachostergios","orcid":"0000-0002-1704-1517","position":14,"is_corresponding":false},{"id":36079,"name":"Daniel H. Kwon","orcid":"0000-0002-0830-7918","position":15,"is_corresponding":false},{"id":36083,"name":"Franklin W. Huang","orcid":"0000-0001-5447-0436","position":16,"is_corresponding":false},{"id":939767,"name":"Bobby Chi-Hung Liaw","orcid":null,"position":17,"is_corresponding":false},{"id":354020,"name":"Scott T. Tagawa","orcid":"0000-0003-2777-8587","position":18,"is_corresponding":false},{"id":63890,"name":"Philip W. Kantoff","orcid":"0000-0001-7275-0597","position":19,"is_corresponding":false},{"id":311748,"name":"Michael J. Morris","orcid":"0000-0002-9454-0096","position":20,"is_corresponding":false},{"id":501295,"name":"William Oh","orcid":"0000-0001-5113-8147","position":21,"is_corresponding":false},{"id":671903,"name":"Neil J. Shah","orcid":"0000-0001-5752-6212","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:27:47.926496Z","pmid":"35657341","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}