{"doi":"10.1093/jnci/djaf197","title":"Group-based trajectories of health-related quality of life among pediatric patients with high-risk Hodgkin lymphoma","abstract":"BACKGROUND: Health-related quality of life (HRQoL) was recently demonstrated to improve throughout therapy for high-risk pediatric Hodgkin lymphoma (HL); however, average scores may not reflect individual differences. This study aimed to identify subgroups of patients with similar HRQoL trajectories from pre- to post-therapy. METHODS: AHOD1331 trial participants aged 11-20 (n = 268; mean [SD] age = 15.6 [1.9]; 48% male) completed the Child Health Ratings Inventories-Global scale (HRQoL) prior to treatment, after cycle 2, after cycle 5, and the end of treatment. Group-based trajectory models (GBTMs) identified latent clusters of individuals with similar HRQoL patterns over time. Multivariable multinomial logistic regression estimated the association between a priori defined characteristics and membership in trajectory-based groups. Log-rank tests examined differences in post-T4 progression-free survival (PFS) by trajectory groups. RESULTS: GBTM identified 3 HRQoL groups: Group 1 (consistently unfavorable [25.7%]), Group 2 (moderate-and-increasing [44.8%]), and Group 3 (consistently favorable [29.5%]). Older age (odds ratio = 1.24, 95% confidence interval = 1.03 to 1.50; P = .022), female sex (2.48, 1.23 to 4.99; P = .011), and Hispanic ethnicity (2.31, 0.97 to 5.50; P = .059) were associated with increased odds of membership in Group 1 vs Group 3. Older age (1.18, 1.00 to 1.39; P = .038) and B-symptoms (2.18, 1.09 to 4.33; P = .027) were associated with increased odds of Group 2 membership vs Group 3. Group membership was not associated with post-T4 PFS. CONCLUSIONS: A subgroup of high-risk pediatric HL patients experience persistently poor HRQoL, starting at diagnosis and continuing through therapy. Age, female sex, Hispanic ethnicity, and B-symptoms were linked to worse HRQoL. These findings can help identify patients at higher risk for poor HRQoL and guide intervention. CLINICALTRIALS.GOV: NCT02166463.","journal":"JNCI Journal of the National Cancer Institute","year":2025,"id":570823,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7863,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02166463"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":731740,"name":"Angie Mae Rodday","orcid":"0000-0002-8671-3401","position":1,"is_corresponding":false},{"id":381789,"name":"Lindsay A. Renfro","orcid":"0000-0002-4306-1896","position":2,"is_corresponding":false},{"id":1128781,"name":"Yue Wu","orcid":"0009-0005-8020-2650","position":3,"is_corresponding":false},{"id":230936,"name":"Tara O. Henderson","orcid":"0000-0001-9394-6206","position":4,"is_corresponding":false},{"id":843891,"name":"Frank G. Keller","orcid":"0009-0004-8919-467X","position":5,"is_corresponding":false},{"id":559297,"name":"Angela Punnett","orcid":"0000-0003-4541-0823","position":6,"is_corresponding":false},{"id":401866,"name":"David Hodgson","orcid":"0000-0003-4687-4582","position":7,"is_corresponding":false},{"id":321130,"name":"Kara M. Kelly","orcid":"0000-0003-1473-3937","position":8,"is_corresponding":false},{"id":282785,"name":"Sharon M. Castellino","orcid":"0000-0001-8367-2002","position":9,"is_corresponding":false},{"id":539568,"name":"Susan K. Parsons","orcid":"0000-0003-0282-6490","position":10,"is_corresponding":false},{"id":570277,"name":"AnnaLynn M. Williams","orcid":"0000-0002-7042-5851","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:57:11.713851Z","pmid":"40700618","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}