{"doi":"10.1093/jnci/djaf104","title":"Father’s occupation and colorectal cancer in his adult offspring","abstract":"BACKGROUND: Growing evidence suggests transmission of colorectal cancer risk through the maternal line. There is scant information about transmission through the paternal line, despite plausible evidence from mammal experiments. METHODS: We examined the association between paternal occupation and colorectal cancer in the Child Health and Development Studies, a multigenerational cohort followed for 60 years. Pregnant mothers completed in-person interviews at enrollment (1959-1966) and reported demographic and health-related information for her and her husband, including occupation. Colorectal cancer in adult (age ≥18 years) offspring was ascertained from a population-based cancer registry. Cox proportional hazards models were used to estimate adjusted hazard ratios (aHRs), with follow-up accrued from birth through cancer diagnosis, death, or last contact. RESULTS: Paternal occupations included 37.0% professional, technical, or managerial; 13.7% clerical or sales; 30.5% crafts or operative; and 17.5% service work or labor. Over 716 133.5 person-years of follow-up, 79 offspring were diagnosed with colorectal cancer (median age at diagnosis: 50 years [range = 23-59 years]). Offspring of fathers employed in crafts, operative, service, or labor occupations had higher incidence rates of colorectal cancer (15.66 per 100 000 person-years; 95% confidence interval [CI] = 11.47 to 20.89) compared with professional, technical, or managerial occupations (6.84 per 100 000 person-years; 95% CI = 3.73 to 11.47). Risk associated with these occupations remained elevated after adjustment for maternal race, paternal education, and offspring year of birth (aHR = 1.99; 95% CI = 1.03 to 3.87). CONCLUSION: Our findings support the possible transmission of cancer risk through the paternal line.","journal":"JNCI Journal of the National Cancer Institute","year":2025,"id":564747,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9395,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1079036,"name":"Emanuelle Dias","orcid":"0000-0001-9040-9376","position":1,"is_corresponding":false},{"id":501600,"name":"Piera M. Cirillo","orcid":"0000-0003-4571-4544","position":2,"is_corresponding":false},{"id":501601,"name":"Nickilou Y. Krigbaum","orcid":"0000-0001-5034-7991","position":3,"is_corresponding":false},{"id":381647,"name":"Barbara A. Cohn","orcid":"0000-0002-9912-8447","position":4,"is_corresponding":false},{"id":319717,"name":"Caitlin C. Murphy","orcid":"0000-0001-9365-0691","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T02:56:24.872312Z","pmid":"40272940","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}