{"doi":"10.1093/jnci/djae253","title":"Grade-stratified meningioma risk among individuals who are non-Hispanic Black and interactions with male sex","abstract":"BACKGROUND: Meningioma risk factors include older age, female sex, and being Black/African American. Limited data explore how meningioma risk in individuals who are Black varies across the lifespan, interacts with sex, and differs by tumor grade. METHODS: The Central Brain Tumor Registry of the United States is a population-based registry covering the entire US population. Meningioma diagnoses from 2004 to 2019 were used to calculate incidence rate ratios for non-Hispanic Black individuals compared with non-Hispanic White individuals across 10-year age intervals and stratified by sex and World Health Organization tumor grade in this retrospective study. RESULTS: A total of 53 890 non-Hispanic Black individuals and 322 373 non-Hispanic White individuals with an intracranial meningioma diagnosis were included in analyses. Beginning in young adulthood, the non-Hispanic Black to non-Hispanic White incidence rate ratio was elevated for grade 1 and grades 2-3 tumors. The incidence rate ratio peaked in the seventh decade of life regardless of grade and was higher for grades 2-3 tumors (incidence rate ratio = 1.57, 95% confidence interval [CI] = 1.46 to 1.69) than grade 1 tumors (incidence rate ratio = 1.27, 95% CI = 1.25 to 1.30) in this age group. The non-Hispanic Black to non-Hispanic White incidence rate ratio was elevated in women (incidence rate ratio = 1.17, 95% CI = 1.16 to 1.18) and was further elevated in men (incidence rate ratio = 1.28, 95% CI = 1.26 to 1.30), revealing synergistic interaction between non-Hispanic Black race and ethnicity and male sex (Pinteraction = .001). CONCLUSIONS: Relative to non-Hispanic White individuals, non-Hispanic Black individuals are at elevated risk of meningioma from young adulthood through old age. Non-Hispanic Black race and ethnicity conferred greater risk of meningioma among men than women and greater risk of grades 2-3 tumors. Population-level differences in meningioma incidence and tumor behavior suggest potential disparities in the geographic, socioeconomic, and racial distribution of meningioma risk factors within the United States.","journal":"JNCI Journal of the National Cancer Institute","year":2024,"id":460218,"datarank":0.3343105101820288,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0928948233169137,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0928948233169137,"corpus_percentile":48.23238183646631,"corpus_rank":6693,"citation_count":4,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.746,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1056068,"name":"Mackenzie Price","orcid":"0000-0001-6369-0609","position":1,"is_corresponding":false},{"id":88538,"name":"David R. Raleigh","orcid":"0000-0001-9299-8864","position":2,"is_corresponding":false},{"id":297411,"name":"Evan Calabrese","orcid":"0000-0002-1464-0354","position":3,"is_corresponding":false},{"id":15709,"name":"Carol Kruchko","orcid":"0000-0001-7212-035X","position":4,"is_corresponding":false},{"id":14321,"name":"Jill S. Barnholtz‐Sloan","orcid":"0000-0001-6190-9304","position":5,"is_corresponding":false},{"id":15705,"name":"Quinn T. Ostrom","orcid":"0000-0003-3469-7558","position":6,"is_corresponding":false},{"id":338823,"name":"Kyle M. Walsh","orcid":"0000-0002-5879-9981","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T02:04:03.568045Z","pmid":"39392420","pmcid":"PMC11807431","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}