{"doi":"10.1093/jnci/djae002","title":"Genetic risk and likelihood of prostate cancer detection on first biopsy by ancestry","abstract":"Despite differences in prostate cancer risk across ancestry groups, relative performance of prostate cancer genetic risks scores (GRS) for positive biopsy prediction in different ancestry groups is unknown. This cross-sectional retrospective analysis examines the association between a polygenic hazard score (PHS290) and risk of prostate cancer diagnosis upon first biopsy in male veterans using 2-sided tests. Our analysis included 36 717 veterans (10 297 of African ancestry). Unadjusted rates of positive first prostate biopsy increased with higher genetic risk (low risk: 34%, high risk: 58%; P < .001). Among men of African ancestry, higher genetic risk was associated with increased prostate cancer detection on first biopsy (odds ratio = 2.18, 95% confidence interval = 1.93 to 2.47), but the effect was stronger among men of European descent (odds ratio = 3.89, 95% confidence interval = 3.62 to 4.18). These findings suggest that incorporating genetic risk into prediction models could better personalize biopsy decisions, although further study is needed to achieve equitable genetic risk stratification among ancestry groups.","journal":"JNCI Journal of the National Cancer Institute","year":2024,"id":467055,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":738345,"name":"Tyler J. Nelson","orcid":"0000-0001-5216-7337","position":1,"is_corresponding":false},{"id":263868,"name":"Alex K. Bryant","orcid":"0000-0003-0194-8381","position":2,"is_corresponding":false},{"id":422539,"name":"Craig C. Teerlink","orcid":"0000-0002-1992-2326","position":3,"is_corresponding":false},{"id":407350,"name":"Roman Gulati","orcid":"0000-0002-7592-6567","position":4,"is_corresponding":false},{"id":23574,"name":"Meghana S. Pagadala","orcid":"0000-0002-7591-6035","position":5,"is_corresponding":false},{"id":280945,"name":"Catherine Tcheandjieu","orcid":"0000-0001-9559-4339","position":6,"is_corresponding":false},{"id":1299948,"name":"Kathryn M. Pridgen","orcid":null,"position":7,"is_corresponding":false},{"id":11351,"name":"Scott L. DuVall","orcid":"0000-0002-4898-3865","position":8,"is_corresponding":false},{"id":313929,"name":"Kosj Yamoah","orcid":"0000-0001-9055-3538","position":9,"is_corresponding":false},{"id":649640,"name":"Jason L. Vassy","orcid":"0000-0001-6113-5564","position":10,"is_corresponding":false},{"id":360589,"name":"Tyler M. Seibert","orcid":"0000-0002-4089-7399","position":11,"is_corresponding":false},{"id":392497,"name":"Richard L. Hauger","orcid":"0000-0003-1509-1868","position":12,"is_corresponding":false},{"id":263871,"name":"Brent S. Rose","orcid":"0000-0002-3197-9552","position":13,"is_corresponding":false},{"id":253980,"name":"Julie A. Lynch","orcid":"0000-0003-0108-2127","position":14,"is_corresponding":false},{"id":445486,"name":"Kyung Min Lee","orcid":"0000-0001-8995-0448","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:05:10.907983Z","pmid":"38212986","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}