{"doi":"10.1093/jnci/djad095","title":"Feasibility and value of genomic profiling in cancer of unknown primary: real-world evidence from prospective profiling study","abstract":"Real-world evidence regarding the value of integrating genomic profiling (GP) in managing cancer of unknown primary (CUP) is limited. We assessed this clinical utility using a prospective trial of 158 patients with CUP (October 2016-September 2019) who underwent GP using next-generation sequencing designed to identify genomic alterations (GAs). Only 61 (38.6%) patients had sufficient tissue for successful profiling. GAs were seen in 55 (90.2%) patients of which GAs with US Food and Drug Administration-approved genomically matched therapy were seen in 25 (40.9%) patients. A change in therapy was recommended and implemented (primary endpoint of the study) in 16 (10.1%) and 4 (2.5%) patients of the entire study cohort, respectively. The most common reason for inability to implement the profiling-guided therapy was worsening of performance status (56.3%). Integrating GP in management of CUP is feasible but challenging because of paucity of tissue and aggressive natural history of the disease and requires innovative precision strategies.","journal":"JNCI Journal of the National Cancer Institute","year":2023,"id":334592,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1064048,"name":"Aakash Tushar Shah","orcid":null,"position":1,"is_corresponding":false},{"id":264368,"name":"Honey V. Reddi","orcid":"0000-0003-1280-9993","position":2,"is_corresponding":false},{"id":1064049,"name":"Priyadarsini Dasari","orcid":null,"position":3,"is_corresponding":false},{"id":536669,"name":"James T. Topham","orcid":"0009-0001-6601-8807","position":4,"is_corresponding":false},{"id":230999,"name":"Hyunsoo Hwang","orcid":"0000-0003-0308-5145","position":5,"is_corresponding":false},{"id":1064050,"name":"Nishat Dhillon","orcid":null,"position":6,"is_corresponding":false},{"id":648303,"name":"Anneleis F. Willett","orcid":"0009-0007-7582-9840","position":7,"is_corresponding":false},{"id":333696,"name":"Brandon G. Smaglo","orcid":"0000-0002-8814-8004","position":8,"is_corresponding":false},{"id":341837,"name":"Jeannelyn S. Estrella","orcid":"0000-0003-3705-5964","position":9,"is_corresponding":false},{"id":65862,"name":"Asif Rashid","orcid":"0000-0001-8463-7321","position":10,"is_corresponding":false},{"id":332454,"name":"Aurelio Matamoros","orcid":"0000-0002-0068-3679","position":11,"is_corresponding":false},{"id":274184,"name":"Michael J. Overman","orcid":"0000-0001-5377-135X","position":12,"is_corresponding":false},{"id":333529,"name":"Linda Choquette","orcid":"0000-0002-6015-5704","position":13,"is_corresponding":false},{"id":1064051,"name":"Greg Omerza","orcid":null,"position":14,"is_corresponding":false},{"id":1063367,"name":"Kevin Kelly","orcid":"0000-0002-4317-9819","position":15,"is_corresponding":false},{"id":293088,"name":"Xuemei Wang","orcid":"0000-0002-3516-0966","position":16,"is_corresponding":false},{"id":274185,"name":"Jonathan M. Loree","orcid":"0000-0001-8189-2132","position":17,"is_corresponding":false},{"id":264369,"name":"Jens Rueter","orcid":"0000-0002-9021-025X","position":18,"is_corresponding":false},{"id":269059,"name":"Gauri R. Varadhachary","orcid":null,"position":19,"is_corresponding":false},{"id":264370,"name":"Kanwal Raghav","orcid":"0000-0003-1311-4173","position":20,"is_corresponding":false},{"id":868765,"name":"Ryan Huey","orcid":"0000-0002-7887-8484","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-19T01:09:53.742667Z","pmid":"37202363","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}