{"doi":"10.1093/jnci/djac208","title":"Association between imaging surveillance frequency and outcomes following surgical treatment of early-stage lung cancer","abstract":"BACKGROUND: Recent studies have suggested that more frequent postoperative surveillance imaging via computed tomography following lung cancer resection may not improve outcomes. We sought to validate these findings using a uniquely compiled dataset from the Veterans Health Administration, the largest integrated health-care system in the United States. METHODS: We performed a retrospective cohort study of veterans with pathologic stage I non-small cell lung cancer receiving surgery (2006-2016). We assessed the relationship between surveillance frequency (chest computed tomography scans within 2 years after surgery) and recurrence-free survival and overall survival. RESULTS: Among 6171 patients, 3047 (49.4%) and 3124 (50.6%) underwent low-frequency (<2 scans per year; every 6-12 months) and high-frequency (≥2 scans per year; every 3-6 months) surveillance, respectively. Factors associated with high-frequency surveillance included being a former smoker (vs current; adjusted odds ratio [aOR] = 1.18, 95% confidence interval [CI] = 1.05 to 1.33), receiving a wedge resection (vs lobectomy; aOR = 1.21, 95% CI = 1.05 to 1.39), and having follow-up with an oncologist (aOR = 1.58, 95% CI = 1.42 to 1.77), whereas African American race was associated with low-frequency surveillance (vs White race; aOR = 0.64, 95% CI = 0.54 to 0.75). With a median (interquartile range) follow-up of 7.3 (3.4-12.5) years, recurrence was detected in 1360 (22.0%) patients. High-frequency surveillance was not associated with longer recurrence-free survival (adjusted hazard ratio = 0.93, 95% CI = 0.83 to 1.04, P = .22) or overall survival (adjusted hazard ratio = 1.04, 95% CI = 0.96 to 1.12, P = .35). CONCLUSIONS: We found that high-frequency surveillance does not improve outcomes in surgically treated stage I non-small cell lung cancer. Future lung cancer treatment guidelines should consider less frequent surveillance imaging in patients with stage I disease.","journal":"JNCI Journal of the National Cancer Institute","year":2022,"id":262667,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.755,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":715286,"name":"Daniel B. Eaton","orcid":"0000-0001-9819-2159","position":1,"is_corresponding":false},{"id":401484,"name":"Su‐Hsin Chang","orcid":"0000-0001-5872-9556","position":2,"is_corresponding":false},{"id":715287,"name":"Yan Yan","orcid":"0000-0002-4618-7654","position":3,"is_corresponding":false},{"id":334404,"name":"Martin W. Schoen","orcid":"0000-0001-6388-5553","position":4,"is_corresponding":false},{"id":919026,"name":"Theodore Thomas","orcid":null,"position":5,"is_corresponding":false},{"id":715288,"name":"Mayank R. Patel","orcid":"0000-0002-0210-9750","position":6,"is_corresponding":false},{"id":273856,"name":"Daniel Kreisel","orcid":"0000-0002-7711-8651","position":7,"is_corresponding":false},{"id":376148,"name":"Ruben G. Nava","orcid":"0000-0001-5685-9445","position":8,"is_corresponding":false},{"id":401482,"name":"Bryan F. Meyers","orcid":"0000-0003-2720-0312","position":9,"is_corresponding":false},{"id":401483,"name":"Benjamin D. Kozower","orcid":"0000-0002-9059-5807","position":10,"is_corresponding":false},{"id":376149,"name":"Varun Puri","orcid":"0000-0001-7761-8421","position":11,"is_corresponding":false},{"id":446033,"name":"Brendan T. Heiden","orcid":"0000-0002-0116-7377","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T00:26:25.074177Z","pmid":"36442509","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}