{"doi":"10.1093/jnci/djac119","title":"Genomic Determinants of Early Recurrences in Low-Stage, Low-Grade Endometrioid Endometrial Carcinoma","abstract":"Low-stage, low-grade endometrioid endometrial carcinoma (EEC), the most common histologic type of endometrial cancer, typically has a favorable prognosis. A subset of these cancers, however, displays an aggressive clinical course with early recurrences, including distant relapses. All statistical tests were 2-sided. Using a combination of whole-exome and targeted capture sequencing of 65 FIGO stage IA and IB grade 1 EECs treated with surgery alone, we demonstrate that chromosome 1q gain (odds ratio [OR] = 8.09, 95% confidence interval [CI] = 1.59 to 54.6; P = .02), PIK3CA mutation (OR = 9.16, 95% CI = 1.95 to 61.8; P = .01), and DNA mismatch repair-deficient molecular subtype (OR = 7.92, 95% CI = 1.44 to 87.6; P = .02) are independent predictors of early recurrences within 3 years in this patient population. Chromosome 1q gain was validated in an independent dataset of stage I grade 1 EECs subjected to whole-exome sequencing. Our findings expand on the repertoire of genomic parameters that should be considered in the evaluation of patients with low-stage, low-grade EEC.","journal":"JNCI Journal of the National Cancer Institute","year":2022,"id":271815,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9498,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":401405,"name":"Marina Stasenko","orcid":"0000-0002-3802-6367","position":1,"is_corresponding":false},{"id":242195,"name":"Pier Selenica","orcid":"0000-0003-0086-0513","position":2,"is_corresponding":false},{"id":238378,"name":"Axel Martin","orcid":"0000-0002-4665-9113","position":3,"is_corresponding":false},{"id":291731,"name":"Edaise M. da Silva","orcid":"0000-0003-3281-7333","position":4,"is_corresponding":false},{"id":313751,"name":"Ana Paula Martins Sebastião","orcid":"0000-0002-2993-577X","position":5,"is_corresponding":false},{"id":937644,"name":"Melissa Krystel‐Whittemore","orcid":null,"position":6,"is_corresponding":false},{"id":258156,"name":"Nadeem R. Abu‐Rustum","orcid":"0000-0001-9689-1298","position":7,"is_corresponding":false},{"id":14428,"name":"Jorge S. Reis‐Filho","orcid":"0000-0003-2969-3173","position":8,"is_corresponding":false},{"id":271413,"name":"Robert A. Soslow","orcid":"0000-0002-7269-5898","position":9,"is_corresponding":false},{"id":235766,"name":"Ronglai Shen","orcid":"0000-0002-8192-7531","position":10,"is_corresponding":false},{"id":298563,"name":"Jennifer J. Mueller","orcid":"0000-0003-0365-7510","position":11,"is_corresponding":false},{"id":315810,"name":"Esther Oliva","orcid":null,"position":12,"is_corresponding":false},{"id":244697,"name":"Britta Weigelt","orcid":"0000-0001-9927-1270","position":13,"is_corresponding":false},{"id":319442,"name":"Nida Safdar","orcid":null,"position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T00:27:39.717534Z","pmid":"35699480","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}