{"doi":"10.1093/jnci/djab040","title":"Prediagnostic Inflammation and Pancreatic Cancer Survival","abstract":"BACKGROUND: Chronic inflammation may promote initiation and progression of pancreatic cancer, but no studies have examined the association between inflammation in the period before diagnosis and pancreatic cancer survival. METHODS: We prospectively examined the association of prediagnostic plasma levels of C-reactive protein, interleukin-6, and tumor necrosis factor-α receptor 2 with survival among 492 participants from 5 large US prospective cohort studies who developed pancreatic cancer. Using an empirical dietary inflammatory pattern (EDIP) score, we evaluated whether long-term proinflammatory diets were associated with survival among 1153 patients from 2 of the 5 cohorts. Cox proportional hazards regression was used to estimate hazard ratios for death with adjustment for potential confounders. All statistical tests were 2-sided. RESULTS: Higher prediagnostic levels of C-reactive protein, interleukin-6, and tumor necrosis factor-α receptor 2 were individually associated with reduced survival (Ptrend = .03, .01, and .04, respectively). Compared with patients with a combined inflammatory biomarker score of 0 (all 3 marker levels below medians), those with a score of 3 (all 3 marker levels above medians) had a hazard ratio for death of 1.57 (95% confidence interval = 1.16 to 2.12; Ptrend = .003), corresponding to median overall survival times of 8 vs 5 months. Patients consuming the most proinflammatory diets (EDIP quartile 4) in the prediagnostic period had a hazard ratio for death of 1.34 (95% confidence interval = 1.13 to 1.59; Ptrend = .01), compared with those consuming the least proinflammatory diets (EDIP quartile 1). CONCLUSION: Prediagnostic levels of inflammatory biomarkers and long-term proinflammatory diets were inversely associated with pancreatic cancer survival.","journal":"JNCI Journal of the National Cancer Institute","year":2021,"id":173268,"datarank":0.9430246102145068,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.4601932364842766,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.4601932364842766,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":23,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":257283,"name":"Vicente Morales‐Oyarvide","orcid":null,"position":1,"is_corresponding":false},{"id":438250,"name":"Natalia Khalaf","orcid":"0000-0002-7585-6183","position":2,"is_corresponding":false},{"id":416221,"name":"Kimberly Perez","orcid":"0000-0002-5745-2994","position":3,"is_corresponding":false},{"id":230958,"name":"Fred K. Tabung","orcid":"0000-0001-8193-7150","position":4,"is_corresponding":false},{"id":594569,"name":"Gloria Y. F. Ho","orcid":"0000-0002-2045-7070","position":5,"is_corresponding":false},{"id":11363,"name":"Charles Kooperberg","orcid":"0000-0002-7986-8560","position":6,"is_corresponding":false},{"id":272433,"name":"Aladdin H. Shadyab","orcid":"0000-0002-9693-0522","position":7,"is_corresponding":false},{"id":337414,"name":"Lihong Qi","orcid":"0000-0002-9108-5390","position":8,"is_corresponding":false},{"id":264806,"name":"Peter Kraft","orcid":"0000-0002-4472-8103","position":9,"is_corresponding":false},{"id":420934,"name":"Howard D. Sesso","orcid":"0000-0002-9698-9954","position":10,"is_corresponding":false},{"id":86230,"name":"Edward L. Giovannucci","orcid":"0000-0002-6123-0219","position":11,"is_corresponding":false},{"id":11268,"name":"JoAnn E. Manson","orcid":"0000-0002-9426-7595","position":12,"is_corresponding":false},{"id":55362,"name":"Meir J. Stampfer","orcid":"0000-0001-8865-935X","position":13,"is_corresponding":false},{"id":3730,"name":"Kimmie Ng","orcid":"0000-0003-0631-1494","position":14,"is_corresponding":false},{"id":75990,"name":"Charles S. Fuchs","orcid":"0000-0003-1582-9842","position":15,"is_corresponding":false},{"id":56410,"name":"Brian M. Wolpin","orcid":"0000-0002-0455-1032","position":16,"is_corresponding":false},{"id":246239,"name":"Ana Babić","orcid":"0000-0003-1199-5958","position":17,"is_corresponding":false},{"id":56399,"name":"Chen Yuan","orcid":"0000-0002-0708-9648","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:45.768135Z","pmid":"33739411","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}