{"doi":"10.1093/jnci/djaa206","title":"Racial Disparities in Epigenetic Aging of the Right vs Left Colon","abstract":"There are well-documented racial differences in age-of-onset and laterality of colorectal cancer. Epigenetic age acceleration is postulated to be an underlying factor. However, comparative studies of side-specific colonic tissue epigenetic aging are lacking. Here, we performed DNA methylation analysis of matched right and left biopsies of normal colon from 128 individuals. Among African Americans (n = 88), the right colon showed accelerated epigenetic aging as compared with individual-matched left colon (1.51 years; 95% confidence interval [CI] = 0.62 to 2.40 years; 2-sided P = .001). In contrast, among European Americans (n = 40), the right colon shows remarkable age deceleration (1.93 years; 95% CI = 0.65 to 3.21 years; 2-sided P = .004). Further, epigenome-wide analysis of DNA methylation identifies a unique pattern of hypermethylation in African American right colon. Our study is the first to report such race and side-specific differences in epigenetic aging of normal colon, providing novel insight into the observed younger age-of-onset and relative preponderance of right-side colon neoplasia in African Americans.","journal":"JNCI Journal of the National Cancer Institute","year":2020,"id":92658,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":463432,"name":"Xiangqing Sun","orcid":"0000-0003-3614-4682","position":1,"is_corresponding":false},{"id":451228,"name":"Fangcheng Yuan","orcid":"0000-0002-8443-6754","position":2,"is_corresponding":false},{"id":463433,"name":"Gregory S. Cooper","orcid":"0000-0002-1019-4326","position":3,"is_corresponding":false},{"id":2244,"name":"Joseph Willis","orcid":"0000-0003-1782-886X","position":4,"is_corresponding":false},{"id":1834,"name":"Daniel J. Weisenberger","orcid":"0000-0001-8303-2603","position":5,"is_corresponding":false},{"id":251132,"name":"Graham Casey","orcid":"0000-0003-1584-5551","position":6,"is_corresponding":false},{"id":218625,"name":"Li Li","orcid":"0000-0003-1802-9517","position":7,"is_corresponding":false},{"id":339673,"name":"Matthew A.M. Devall","orcid":"0000-0001-5943-4397","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-18T22:30:31.563852Z","pmid":"33377907","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}