{"doi":"10.1093/jn/131.2.287","title":"High Levels of Dietary Carnosine Are Associated with Increased Concentrations of Carnosine and Histidine in Rat Soleus Muscle","abstract":null,"journal":"The Journal of Nutrition","year":2001,"id":604561,"datarank":3.5042150203033353,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"self_citation_contribution":0.5837730447165941,"citation_network_contribution":2.920441975586741,"self_endowment_contribution":0.5837730447165941,"citer_contribution":2.920441975586741,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":48,"citers_with_citation_signal":46,"citers_with_endowment":46,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1551203,"name":"Gilbert A. Boissonneault","orcid":null,"position":1,"is_corresponding":false},{"id":1551204,"name":"Ching K. Chow","orcid":null,"position":2,"is_corresponding":false},{"id":1551205,"name":"Geza G. Bruckner","orcid":null,"position":3,"is_corresponding":false},{"id":968749,"name":"L. Michele Maynard","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"High Levels of Dietary Carnosine Are Associated with Increased Concentrations of Carnosine and Histidine in Rat Soleus Muscle","abstract":"The aims of this investigation were to: 1) determine the effect of a moderately high dose of carnosine on muscle concentrations of carnosine, histidine and vitamin E at deficient, minimally adequate and sufficient levels of dietary vitamin E and 2) compare the effects of moderately high and pharmacological doses of carnosine on muscle concentrations of carnosine, histidine and vitamin E when dietary vitamin E is minimally adequate. Muscle concentrations of carnosine, histidine and vitamin E were measured in the lateral gastrocnemius and red and white vastus lateralis; carnosine and histidine concentrations were also measured in soleus muscle. Male Sprague-Dawley rats (n = 12/group) were fed a basal vitamin E-deficient diet supplemented with either 0, 0.001 or 0.01% vitamin E and 0, 0.1 or 1.8% carnosine. After 8 wk, 1.8% carnosine resulted in significant fivefold increases in carnosine and twofold increases in histidine in the soleus muscle (P < or = 0.05). Muscle vitamin E concentrations were not significantly affected by dietary carnosine. Thus, very high levels of dietary carnosine are associated with increases in carnosine and histidine concentrations in rat soleus muscle.","is_dataset_classified":null,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11160547","pmcid":null,"openalex_id":"https://openalex.org/W2135884530","authors":[],"funders":[],"total_grants":0,"fwci":0.4462,"citation_percentile":0.61833731,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":2},{"year":2014,"count":3},{"year":2015,"count":1},{"year":2016,"count":6},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022316622146249?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022316622146249?httpAccept=text/plain","host_type":"publisher"},{"url":"http://academic.oup.com/jn/article-pdf/131/2/287/24015456/4w020100287.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/jn/131.2.287","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11160547","host_type":"repository"}],"fields_of_study":["Biochemical effects in animals","Free Radicals and Antioxidants","Stress Responses and Cortisol","Animals","Antioxidants","Carnosine","Dose-Response Relationship, Drug","Histidine","Male","Muscle Fibers, Fast-Twitch","Muscle Fibers, Slow-Twitch","Muscle, Skeletal","Random Allocation","Rats","Rats, Sprague-Dawley","Vitamin E","Vitamin E Deficiency"],"mesh_terms":["Animals","Antioxidants","Carnosine","Dose-Response Relationship, Drug","Histidine","Male","Random Allocation","Vitamin E","Vitamin E Deficiency","Rats, Sprague-Dawley","Muscle, Skeletal","Muscle Fibers, Fast-Twitch","Muscle Fibers, Slow-Twitch","Rats"],"keywords":["Carnosine","Histidine","Soleus muscle","Vitamin","Internal medicine","Endocrinology","Anserine","Chemistry","Vitamin E","Biochemistry","Skeletal muscle","Biology","Medicine","Antioxidant","Enzyme"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:25:13.584209Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}