{"doi":"10.1093/jn/126.1.138","title":"Selenoprotein P Concentration in Plasma is an Index of Selenium Status in Selenium-Deficient and Selenium-Supplemented Chinese Subjects","abstract":null,"journal":"The Journal of Nutrition","year":1996,"id":616149,"datarank":0.8020661296076204,"base_score":5.3471075307174685,"endowment":5.3471075307174685,"self_citation_contribution":0.8020661296076204,"citation_network_contribution":0.0,"self_endowment_contribution":0.8020661296076204,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":209,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":535917,"name":"Yiming Xia","orcid":null,"position":1,"is_corresponding":false},{"id":1588397,"name":"Björn Åkesson","orcid":null,"position":2,"is_corresponding":false},{"id":1588398,"name":"Martha E. Boeglin","orcid":null,"position":3,"is_corresponding":false},{"id":293455,"name":"Raymond F. Burk","orcid":null,"position":4,"is_corresponding":false},{"id":291501,"name":"Kristina E. Hill","orcid":"0000-0002-4601-0760","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Selenoprotein P Concentration in Plasma is an Index of Selenium Status in Selenium-Deficient and Selenium-Supplemented Chinese Subjects","abstract":"Selenoprotein P, a selenium-rich plasma protein, is an index of selenium status in rats. Antibodies against human selenoprotein P were raised to study the protein and to develop a radioimmunoassay for it. A single collection of plasma from a healthy person in the United States contained 1.84 mumol selenium/L and was defined as containing 1 Unit (U) selenoprotein P/L. Removal of selenoprotein P from the reference plasma by an antibody column indicated that 0.81 mumol selenium/L, or 44% of the plasma selenium, was present as selenoprotein P. Work by others had determined that glutathione peroxidase accounted for 12% of plasma selenium. Stored plasma samples from selenium-deficient (Dechang County) and selenium-supplemented (Mianning County) populations in China were assayed for selenoprotein P. Boys aged 8-12 y had selenoprotein P concentrations of 0.10 +/- 0.04 U/L (n = 22) in Dechang and 0.39 +/- 0.17 U/L (n = 17) in Mianning. Supplementation with 100 micrograms selenium as selenate per day for 14 d raised those levels to 0.51 +/- 0.13 U/L in Dechang and to 0.76 +/- 0.27 U/L in Mianning. Similar results were obtained in men, and plasma selenium concentrations correlated with selenoprotein P concentrations. A study comparing indices of selenium status was conducted in the two counties. Selenoprotein P concentration in Dechang subjects (n = 79) was 36% of that in Mianning subjects (n = 117). For plasma glutathione peroxidase activity the value was 54%; for plasma selenium, 47%; and for whole blood selenium, 64%. We conclude that selenoprotein P is the major selenoprotein in human plasma and that its concentration is an index of selenium nutritional status that appears to be as sensitive as other indices in common use.","is_dataset_classified":null,"base_score":5.3471075307174685,"endowment":5.3471075307174685,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8558294","pmcid":null,"openalex_id":"https://openalex.org/W2115789215","authors":[],"funders":[{"funder_name":"NIEHS NIH HHS","grant_id":"ES 06093","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK 26657","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL 36371","title":null}],"total_grants":3,"fwci":5.1248,"citation_percentile":0.96151644,"influential_citations":0,"citation_trend":[{"year":2012,"count":9},{"year":2013,"count":3},{"year":2014,"count":11},{"year":2015,"count":13},{"year":2016,"count":6},{"year":2017,"count":3},{"year":2018,"count":8},{"year":2019,"count":2},{"year":2020,"count":10},{"year":2021,"count":5},{"year":2022,"count":5},{"year":2023,"count":5},{"year":2024,"count":2},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://academic.oup.com/jn/article-pdf/126/1/138/24073008/jn1260010138.pdf","host_type":"journal"},{"url":"https://academic.oup.com/jn/article-pdf/126/1/138/24073008/jn1260010138.pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022316622014274?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022316622014274?httpAccept=text/plain","host_type":"publisher"},{"url":"http://academic.oup.com/jn/article-pdf/126/1/138/24073008/jn1260010138.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/jn/126.1.138","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8558294","host_type":"repository"}],"fields_of_study":["Selenium in Biological Systems","Medical and Biological Ozone Research","Trace Elements in Health","Adolescent","Adult","Aged","Aging","Analysis of Variance","Child","Child, Preschool","China","Female","Food, Fortified","Glutathione Peroxidase","Health Status Indicators","Humans","Linear Models","Male","Middle Aged","Proteins","Radioimmunoassay","Selenium","Selenoprotein P","Selenoproteins","United States"],"mesh_terms":["Adolescent","Adult","Aged","Aging","Analysis of Variance","Child","Child, Preschool","China","Female","Food, Fortified","Glutathione Peroxidase","Health Status Indicators","Humans","Male","Middle Aged","Proteins","Radioimmunoassay","Selenium","United States","Linear Models","Selenoproteins","Selenoprotein P"],"keywords":["Selenium","Selenoprotein P","Selenoprotein","Glutathione peroxidase","Chemistry","Peroxidase","Blood plasma","Endocrinology","Internal medicine","Radioimmunoassay","Biochemistry","Biology","Glutathione","Medicine","Enzyme"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T22:05:55.154140Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}