{"doi":"10.1093/jmcb/mjaa017","title":"Inhibition of tumor suppressor p73 by nerve growth factor receptor via chaperone-mediated autophagy","abstract":"The tumor suppressr p73 is a homolog of p53 and is capable of inducing cell cycle arrest and apoptosis. Here, we identify nerve growth factor receptor (NGFR, p75NTR, or CD271) as a novel negative p73 regulator. p73 activates NGFR transcription, which, in turn, promotes p73 degradation in a negative feedback loop. NGFR directly binds to p73 central DNA-binding domain and suppresses p73 transcriptional activity as well as p73-mediated apoptosis in cancer cells. Surprisingly, we uncover a previously unknown mechanism of NGFR-facilitated p73 degradation through the chaperone-mediated autophagy (CMA) pathway. Collectively, our studies demonstrate a new oncogenic function for NGFR in inactivating p73 activity by promoting its degradation through the CMA.","journal":"Journal of Molecular Cell Biology","year":2020,"id":85897,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":438351,"name":"Kun Yang","orcid":"0000-0001-6729-2552","position":1,"is_corresponding":false},{"id":439162,"name":"Lucia J. Chiao","orcid":null,"position":2,"is_corresponding":false},{"id":439163,"name":"Yun Deng","orcid":null,"position":3,"is_corresponding":false},{"id":336455,"name":"Xiang Zhou","orcid":"0000-0002-1172-7948","position":4,"is_corresponding":false},{"id":438352,"name":"Zhen Zhang","orcid":"0000-0001-7825-2679","position":5,"is_corresponding":false},{"id":336460,"name":"Shelya X. Zeng","orcid":"0000-0001-5195-9420","position":6,"is_corresponding":false},{"id":304513,"name":"Hua Lu","orcid":"0000-0002-9285-7209","position":7,"is_corresponding":false},{"id":438350,"name":"Daniel Nguyen","orcid":"0000-0003-3157-8107","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-18T21:58:16.217017Z","pmid":"32285119","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}