{"doi":"10.1093/jleuko/qiaf015","title":"The role of CD57+γδ T cells in the immune pathogenesis of patients with sepsis","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>The immune responses are dysregulated during sepsis. This study aimed to investigate the role of CD57+γδ T cells in the immune pathogenesis of patients with sepsis. We characterized the transcriptomic profile of peripheral γδ T cells from patients with sepsis using smart RNA sequencing. Additionally, we assessed the ratios and immune functional signatures of CD57+γδ T cells in sepsis through flow cytometry. The cytotoxic capacity of the CD57+γδ T-cell subset was also validated in vitro. Our findings revealed a reduction in the proportion of peripheral CD57+γδ T cells in patients with sepsis, which was correlated with clinical outcomes. Compared with CD57−γδ T cells, CD57+γδ T cells exhibited a markedly altered immunophenotype, including decreased expression of costimulatory molecules and increased expression of proinflammatory factors and cytotoxic granules. Our study proposed a potential role of CD57 in sepsis and its utility as a novel biomarker for patients with sepsis.</jats:p>","journal":"Journal of Leukocyte Biology","year":2025,"id":612423,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1576832,"name":"Nenggang Jiang","orcid":null,"position":1,"is_corresponding":false},{"id":1576833,"name":"Yongmei Jin","orcid":null,"position":2,"is_corresponding":false},{"id":1251581,"name":"Chuan Yang","orcid":null,"position":3,"is_corresponding":false},{"id":1469407,"name":"Yang Fu","orcid":"0000-0002-0378-2410","position":4,"is_corresponding":false},{"id":1576831,"name":"Liman Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The role of CD57+γδ T cells in the immune pathogenesis of patients with sepsis","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>The immune responses are dysregulated during sepsis. This study aimed to investigate the role of CD57+γδ T cells in the immune pathogenesis of patients with sepsis. We characterized the transcriptomic profile of peripheral γδ T cells from patients with sepsis using smart RNA sequencing. Additionally, we assessed the ratios and immune functional signatures of CD57+γδ T cells in sepsis through flow cytometry. The cytotoxic capacity of the CD57+γδ T-cell subset was also validated in vitro. Our findings revealed a reduction in the proportion of peripheral CD57+γδ T cells in patients with sepsis, which was correlated with clinical outcomes. Compared with CD57−γδ T cells, CD57+γδ T cells exhibited a markedly altered immunophenotype, including decreased expression of costimulatory molecules and increased expression of proinflammatory factors and cytotoxic granules. Our study proposed a potential role of CD57 in sepsis and its utility as a novel biomarker for patients with sepsis.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39936498","pmcid":null,"openalex_id":"https://openalex.org/W4407388936","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82002215","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82100075","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82402702","title":null},{"funder_name":"Natural Science Foundation of Sichuan Province","grant_id":"2023NSFSC1483","title":null}],"total_grants":4,"fwci":0.0,"citation_percentile":0.01996113,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://academic.oup.com/jleukbio/advance-article-pdf/doi/10.1093/jleuko/qiaf015/61857839/qiaf015.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/jleukbio/article-pdf/117/4/qiaf015/61857839/qiaf015.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/jleuko/qiaf015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39936498","host_type":"repository"}],"fields_of_study":["Immune Response and Inflammation","Sepsis Diagnosis and Treatment","Inflammasome and immune disorders"],"mesh_terms":["Intraepithelial Lymphocytes","Aged","Female","Humans","Male","Middle Aged","Biomarkers","Immunophenotyping","T-Lymphocyte Subsets","Receptors, Antigen, T-Cell, gamma-delta","Sepsis","CD57 Antigens"],"keywords":["Pathogenesis","Biology","Immune system","Sepsis","Immunology","CD57","Immunopathogenesis","Γδ T Cell"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T03:21:13.212858Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}