{"doi":"10.1093/jleuko/qiae242","title":"Piezo1 restrains proinflammatory response but is essential in T-cell–mediated immunopathology","abstract":"Piezo1 is a mechanosensitive, nonselective Ca2+ channel that is broadly expressed in CD4+ T cells. Using lineage-specific Piezo1 knockout mice (Piezo1cKO), we show that loss of Piezo1 in CD4+ T cells significantly increased IFNγ and IL-17 production in vitro under TH1 and TH17 polarizing conditions, respectively. Despite their intrinsic proinflammatory phenotype, Piezo1cKO T cells are incapable of establishing disease in vivo in 3 separate adoptive transfer T-cell-mediated inflammatory mouse models, including experimental autoimmune encephalomyelitis, inflammatory bowel disease, and graft-vs-host disease. These phenomena coincided with a decreased effector memory (CD44hiCD62Llo) CD4+ T-cell pool derived from donor Piezo1cKO T cells, an observation related to intrinsic T-cell fitness, as a cotransfer inflammatory bowel disease mouse model revealed a deficiency in the CD4+ effector memory population derived only from the naive Piezo1cKO but a not coinfused Piezo1WT CD4+ T-cell source. Taken together, our results support Piezo1 as restraining proinflammatory T-cell differentiation while contributing to the generation and persistence of the effector memory pool during CD4+ T-cell-mediated immunopathology.","journal":"Journal of Leukocyte Biology","year":2024,"id":427976,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.942,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1050799,"name":"Alicia Santin","orcid":"0000-0002-5638-0861","position":1,"is_corresponding":false},{"id":672311,"name":"Jay Myers","orcid":"0000-0003-2574-0438","position":2,"is_corresponding":false},{"id":360781,"name":"Byung‐Gyu Kim","orcid":"0000-0002-8921-5061","position":3,"is_corresponding":false},{"id":410272,"name":"Saada Eid","orcid":null,"position":4,"is_corresponding":false},{"id":1050798,"name":"Suzanne L. Tomchuck","orcid":"0000-0002-4068-3470","position":5,"is_corresponding":false},{"id":890403,"name":"Daniel Kingsley","orcid":"0000-0002-5767-6509","position":6,"is_corresponding":false},{"id":672313,"name":"Alex Y. Huang","orcid":"0000-0002-5701-4521","position":7,"is_corresponding":false},{"id":360778,"name":"Sung Hee Choi","orcid":"0000-0002-8102-5538","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T01:58:52.576447Z","pmid":"39492686","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}