{"doi":"10.1093/jleuko/qiae219","title":"B-cell interleukin 1 receptor 1 modulates the female adipose tissue immune microenvironment during aging","abstract":"Myeloid cell production of interleukin-1β (IL-1β) drives inflammaging in visceral white adipose tissue (vWAT) and contributes to the expansion of interleukin-1 receptor 1 (Il1r1)-positive aged adipose B cells (AABs). AABs promote metabolic dysfunction and inflammation under inflammatory challenges. However, whether IL-1β contributes to AAB-associated inflammation during aging is unclear. Using a B-cell-specific knockout of Il1r1 (BKO mice), we characterized old vWAT in the absence of IL-1β-B-cell signaling. In addition to sex-specific metabolic improvements in females, we identified a reduction in the proportion of B cells and a sex-specific increase in the B1/B2 B-cell ratio in BKO vWAT. Using single-cell RNA sequencing of vWAT immune cells, we observed that BKO differentially affected inflammatory signaling in vWAT immune cells. These data suggest that IL-1β-B-cell signaling supports the inflammatory response in multiple cell types and provides insight into the complex microenvironment in aged vWAT.","journal":"Journal of Leukocyte Biology","year":2024,"id":450744,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9588,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":802258,"name":"Louise E. Pitcher","orcid":null,"position":1,"is_corresponding":false},{"id":841559,"name":"In Hwa Jang","orcid":"0009-0009-9448-8433","position":2,"is_corresponding":false},{"id":1215039,"name":"Katie Nguyen","orcid":null,"position":3,"is_corresponding":false},{"id":396305,"name":"Stephanie H. Cholensky","orcid":null,"position":4,"is_corresponding":false},{"id":233167,"name":"Paul D. Robbins","orcid":"0000-0003-1068-7099","position":5,"is_corresponding":false},{"id":566975,"name":"Christina D. Camell","orcid":"0000-0001-7847-3543","position":6,"is_corresponding":false},{"id":1214371,"name":"Anna Carey","orcid":"0000-0001-6735-6077","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:02:28.969209Z","pmid":"39378334","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}