{"doi":"10.1093/jleuko/qiae192","title":"Attenuation of HIV-specific T cell responses Among people with HIV on ART following dipyridamole treatment","abstract":"Twelve weeks of dipyridamole increased extracellular adenosine levels and decreased T cell activation in people with human immunodeficiency virus (HIV). In this analysis, we investigated the effect of dipyridamole on HIV-specific T cell responses. We compared changes in Gag- and Env-specific T cell responses using intracellular cytokine staining, following 12 wk of dipyridamole treatment vs placebo. We evaluated whether frequencies of polyfunctional HIV-specific T cells were associated with purines in the adenosine pathway and with measures of HIV persistence and chronic inflammation. There was a significant decrease in CD4+ polyfunctional T cell responses to Gag (-62.6% vs -23.0%; P < 0.001) and Env (-56.1% vs -6.0%; P < 0.001) in the dipyridamole arm. In the dipyridamole group, lower frequencies of polyfunctional Env-specific CD4+ T cells were associated with higher plasma levels of adenosine (r = -0.85, P < 0.01) and inosine (r = -0.70, P = 0.04). Higher adenosine levels induced by dipyridamole treatment is associated with decreased HIV-specific CD4+ T cell polyfunctional responses in people with HIV on antiretroviral therapy.","journal":"Journal of Leukocyte Biology","year":2024,"id":473976,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9433,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":756727,"name":"Emily A Hixson","orcid":null,"position":1,"is_corresponding":false},{"id":631194,"name":"Cynthia Klamar-Blain","orcid":null,"position":2,"is_corresponding":false},{"id":265612,"name":"Delbert G. Gillespie","orcid":null,"position":3,"is_corresponding":false},{"id":423729,"name":"Kaleab Z. Abebe","orcid":"0000-0002-3644-8419","position":4,"is_corresponding":false},{"id":259560,"name":"Charles R. Rinaldo","orcid":"0000-0002-9194-3164","position":5,"is_corresponding":false},{"id":258969,"name":"John W. Mellors","orcid":"0000-0002-3737-9742","position":6,"is_corresponding":false},{"id":264558,"name":"Edwin K. Jackson","orcid":"0000-0002-8101-6009","position":7,"is_corresponding":false},{"id":259558,"name":"Sharon A. Riddler","orcid":"0000-0002-2545-7037","position":8,"is_corresponding":false},{"id":259559,"name":"Bernard Macatangay","orcid":"0000-0002-0405-0991","position":9,"is_corresponding":false},{"id":1310595,"name":"Benjamin C Morris","orcid":null,"position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-19T02:06:09.108857Z","pmid":"39217408","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}