{"doi":"10.1093/jimmun/vkaf328","title":"SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport","abstract":"B cells play critical roles in humoral immunity to infection, vaccination, and autoimmunity. The differentiation of B cells into antibody-producing plasma cells (PCs) has been extensively studied, but the role of metabolic transporters that mediate nutrient uptake during PC differentiation is not well-understood. Here, we characterized the dependence of B cells and PC differentiation on the neutral amino acid transporter SLC7A5. We demonstrate that SLC7A5 promotes B cell functions including proliferation and PC differentiation in vitro and in vivo after immunization with T dependent and independent antigens. Deletion of SLC7A5 in B cells suppressed the function of mTORC1 and enforced mTORC1 activity rescued PC differentiation. The role of SLC7A5 in B cells appears to be unrelated to leucine uptake because B cells were insensitive to extracellular leucine depletion. Defects in SLC7A5-deficient B cells could, however, be rescued by extracellular methionine supplementation, suggesting a role for methionine in SLC7A5-dependent B cell function and PC differentiation. Our study provides evidence for a leucine-independent role of SLC7A5 in B cell function and PC differentiation.","journal":"The Journal of Immunology","year":2025,"id":585236,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1498610,"name":"Ke Hu","orcid":"0009-0000-5948-7384","position":1,"is_corresponding":false},{"id":325423,"name":"Lucile Noyer","orcid":"0000-0002-1369-684X","position":2,"is_corresponding":false},{"id":266518,"name":"Li Zhong","orcid":"0000-0003-3094-4806","position":3,"is_corresponding":false},{"id":882402,"name":"Wenyi Li","orcid":"0000-0002-5436-1317","position":4,"is_corresponding":false},{"id":1498611,"name":"Liwei Wang","orcid":"0009-0002-1666-4058","position":5,"is_corresponding":false},{"id":244372,"name":"Stefan Feske","orcid":"0000-0001-5431-8178","position":6,"is_corresponding":false},{"id":882401,"name":"Anthony Tao","orcid":"0000-0003-0978-2769","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T02:59:20.067334Z","pmid":"41389221","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}