{"doi":"10.1093/jimmun/vkaf283.210","title":"Cx3cr1 deficiency alters renal-infiltrating immune cell transcriptional landscape in lupus-prone MRL/lpr mice 2274","abstract":"Abstract Description Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by aberrant immune responses and chronic inflammation. CX3CR1, a chemokine receptor, plays a critical role in immune cell trafficking and lupus pathogenesis. We previously found that Cx3cr1 deficiency exacerbates murine lupus nephritis, but the mechanisms remain unclear. Using single-cell RNA sequencing (scRNA-seq), we analyzed renal-infiltrating CD45+ leukocytes from wild-type (WT) and Cx3cr1-knockout (KO) lupus-prone MRL/lpr mice. scRNA-seq revealed transcriptional changes in T cells, B cells, NK cells, neutrophils, monocytes, macrophages, and dendritic cells. In KO mice, macrophages exhibited upregulation of complement-related genes, including C1qa, C1qb, C1qc, and C3ar1, indicating enhanced complement activation. In addition, Egfr was upregulated in CD4 T cells, dendritic cells, B cells, NK cells, neutrophils, double negative T cells, and macrophages, suggesting a role for epidermal growth factor (EGF) in autoimmune activation and proliferation. Pathway analysis showed activation of complement, coagulation, and EGF-associated pathways in various immune cell subsets. These findings suggest that Cx3cr1 deficiency alters the transcriptional landscape of renal-infiltrating immune cells to exacerbate lupus nephritis in MRL/lpr mice. Topic Categories Basic Autoimmunity (BA)","journal":"The Journal of Immunology","year":2025,"id":582488,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9622,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":384765,"name":"Qin Xu","orcid":"0000-0002-7772-9444","position":1,"is_corresponding":false},{"id":1068448,"name":"Razan Alajoleen","orcid":"0000-0003-4623-9167","position":2,"is_corresponding":false},{"id":1312430,"name":"Rana Estaleen","orcid":null,"position":3,"is_corresponding":false},{"id":744373,"name":"David N Oakland","orcid":"0000-0002-7256-912X","position":4,"is_corresponding":false},{"id":323342,"name":"Fengyi Wan","orcid":"0000-0001-9216-9767","position":5,"is_corresponding":false},{"id":499277,"name":"Christopher M. Reilly","orcid":"0000-0003-4787-7750","position":6,"is_corresponding":false},{"id":459057,"name":"Song Li","orcid":"0000-0002-0661-4893","position":7,"is_corresponding":false},{"id":497993,"name":"Xin Luo","orcid":"0000-0002-2809-5836","position":8,"is_corresponding":false},{"id":544137,"name":"Tian Xu","orcid":"0009-0004-6859-9491","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:58:55.657290Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}