{"doi":"10.1093/jimmun/vkaf264","title":"Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice","abstract":"The liver contains a diverse repertoire of leukocytes, with liver B cells representing a significant population of hepatic immune cells in both newborns and adults. Despite their importance, these cells remain largely unexplored. In this study, we comprehensively characterized liver B cells from newborns through adulthood in both humans and mice applying a combination of in vivo imaging, immunophenotyping, RNA sequencing, and cell transfer protocols to characterize hepatic B cell subtypes from birth to adulthood. We found that newborn liver B cell population are transcriptionally and phenotypically distinct from those in adults, with significant alterations in genes related to immunoglobulin processing, release, and major histocompatibility complex class I and II functions. Photoconversion-based tracking revealed that liver-resident B cells actively migrate to distant lymphoid organs, including the spleen and bone marrow, where they integrate into the mature immune cell pool. Our findings establish the newborn liver as a crucial niche for B cell maturation and migration, highlighting its role in seeding secondary lymphoid organs and contributing to immune function throughout life. These insights provide new understanding of liver-derived B cells in the postnatal development of the immune system.","journal":"The Journal of Immunology","year":2025,"id":579120,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.939,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1260082,"name":"Marília Garcia de Oliveira","orcid":"0000-0002-4719-5752","position":1,"is_corresponding":false},{"id":1489360,"name":"Brenda Naemi Nakagaki","orcid":"0000-0002-5597-2726","position":2,"is_corresponding":false},{"id":1489361,"name":"M. 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