{"doi":"10.1093/jimmun/vkaf249","title":"Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity","abstract":"Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions systemic responses are poorly understood. Here, we leveraged a highly compartmentalized model of skin inflammation and identified a surprising type I interferon (IFN)-mediated activation of hematopoietic stem/progenitor cells (HSPCs) that results in profound changes to systemic host responses. Post-inflamed mice were protected from atherosclerosis and had worse outcomes following influenza virus infection. This IFN-mediated HSPC modulation was dependent on IFNAR signaling and could be recapitulated with the administration of recombinant IFN-α. Importantly, the transfer of post-inflamed HSPCs was sufficient to transmit the immune suppression phenotype. IFN modulation of HSPCs was rooted both in long-term changes in chromatin accessibility and the emergence of an IFN-responsive functional state from multiple progenitor populations. Collectively, our data reveal the profound and enduring effect of transient inflammation and more specifically type I IFN signaling and set the stage for a more nuanced understanding of HSPC functional modulation by peripheral immune signals.","journal":"The Journal of Immunology","year":2025,"id":542461,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1432035,"name":"Wenceslao Martinez-Navarrete","orcid":null,"position":1,"is_corresponding":false},{"id":278014,"name":"Jack Major","orcid":"0000-0002-8018-1512","position":2,"is_corresponding":false},{"id":1020014,"name":"Ipsita Subudhi","orcid":"0000-0003-0191-6953","position":3,"is_corresponding":false},{"id":850721,"name":"Varvara Paraskevopoulou","orcid":"0000-0002-5007-9955","position":4,"is_corresponding":false},{"id":1020013,"name":"Aleksandr Prystupa","orcid":"0000-0001-6065-9024","position":5,"is_corresponding":false},{"id":863263,"name":"Ikjot Sidhu","orcid":"0000-0002-1470-6421","position":6,"is_corresponding":false},{"id":75636,"name":"Anna H. Yeaton","orcid":"0000-0002-7654-371X","position":7,"is_corresponding":false},{"id":1432036,"name":"Filadelfia Tadjibaeva","orcid":null,"position":8,"is_corresponding":false},{"id":1167358,"name":"Maria Laskou","orcid":null,"position":9,"is_corresponding":false},{"id":774637,"name":"Carmen Hannemann","orcid":"0000-0002-2573-0152","position":10,"is_corresponding":false},{"id":1167357,"name":"Casey Donahoe","orcid":null,"position":11,"is_corresponding":false},{"id":1047300,"name":"Destini Wiseman","orcid":"0009-0007-2028-0707","position":12,"is_corresponding":false},{"id":1432037,"name":"Riley Hamilton","orcid":null,"position":13,"is_corresponding":false},{"id":109597,"name":"Iannis Aifantis","orcid":"0000-0001-6857-1035","position":14,"is_corresponding":false},{"id":225196,"name":"Shruti Naik","orcid":"0000-0002-2216-5135","position":15,"is_corresponding":false},{"id":677046,"name":"Ada Weinstock","orcid":"0000-0003-3619-3388","position":16,"is_corresponding":false},{"id":831933,"name":"María Guillamot","orcid":"0000-0001-6970-5250","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:52:55.809501Z","pmid":"41076641","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}