{"doi":"10.1093/jimmun/vkaf035","title":"Lung-resident memory CD4+ T cells are dependent on <i>Batf3</i>","abstract":"Tissue-resident memory cells contribute to allergen-induced inflammation and airway hyperresponsiveness, but relatively little is known of the cellular and molecular mechanisms underlying the accumulation of these cells in the lung. Here, we show that allergen-specific CD4+ resident memory T cells are virtually absent in lungs of mice lacking Batf3, a transcription factor required for the development of type 1 lung dendritic cells (cDC1). These animals become sensitized to inhaled allergens and display normal responses in a short-term house dust mite-dependent model of asthma. However, they have strongly reduced airway inflammation and weak airway hyperresponsiveness in a similar, but long-term model of asthma. Single-cell RNA sequencing revealed that Batf3-deficient mice lack a subset of lung-resident CD4+ T cells characterized by expression of the chemokine receptor-encoding gene, Cxcr6. Together, these data show that Batf3 promotes the development of CD4+ resident memory T cells and thus allergic responses to inhaled allergens.","journal":"The Journal of Immunology","year":2025,"id":523021,"datarank":0.27395147533251357,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.03253578846739851,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.03253578846739851,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9439,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":597585,"name":"Hideki Nakano","orcid":"0000-0002-6343-4709","position":1,"is_corresponding":false},{"id":402200,"name":"Gregory S. Whitehead","orcid":"0000-0003-3654-6446","position":2,"is_corresponding":false},{"id":427192,"name":"Christina L. Wilkinson","orcid":null,"position":3,"is_corresponding":false},{"id":597587,"name":"Keiko Nakano","orcid":"0000-0003-2735-4119","position":4,"is_corresponding":false},{"id":563384,"name":"Abdull J. Massri","orcid":"0000-0003-1314-6650","position":5,"is_corresponding":false},{"id":305243,"name":"Donald N. Cook","orcid":"0000-0002-0052-3755","position":6,"is_corresponding":false},{"id":784343,"name":"A. Patterson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:49:58.707747Z","pmid":"40184040","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}