{"doi":"10.1093/jimmun/vkae045","title":"IL-2Rα is dispensable for murine B cell development and humoral response","abstract":"The cytokine IL-2 plays a pivotal role in the immune system, specifically in the proliferation of T, B, and NK cells. The alpha subunit of the IL-2 receptor, IL-2Rα (CD25), is known to regulate the expansion and differentiation of T lymphocytes. CD25 is also expressed in developing B cells; however, its B cell intrinsic role remains undefined. We generated a mouse model with a B cell-specific deletion of CD25 to ascertain its role in B cell development and function. Unexpectedly, we found that the loss of CD25 had no impact on B cell development, homeostasis, or immune response to model antigens. Additionally, while CD25 expression was upregulated in activated splenic B cells, its absence did not affect class switch recombination in vitro or in vivo. We conclude that in contrast to its critical role in T cell differentiation and function, and despite its expression in developing and activated B cells, CD25 does not have any significant role in B cell development and adaptive immune functions.","journal":"The Journal of Immunology","year":2025,"id":525382,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":665550,"name":"Kalina T. Belcheva","orcid":null,"position":1,"is_corresponding":false},{"id":664706,"name":"Ryan Smolkin","orcid":"0000-0002-8353-2672","position":2,"is_corresponding":false},{"id":664709,"name":"Montserrat Cols","orcid":"0000-0001-6578-8378","position":3,"is_corresponding":false},{"id":1400134,"name":"Jason D. Fontenot","orcid":"0000-0002-5106-0519","position":4,"is_corresponding":false},{"id":567654,"name":"William T. Yewdell","orcid":"0000-0002-5712-1896","position":5,"is_corresponding":false},{"id":415573,"name":"Jayanta Chaudhuri","orcid":"0000-0002-3838-0075","position":6,"is_corresponding":false},{"id":215576,"name":"Priyanka Chowdhury","orcid":null,"position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T02:50:21.274116Z","pmid":"40096628","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}