{"doi":"10.1093/jimmun/vkae027","title":"T-bet–expressing B cells promote atherosclerosis in apolipoprotein E–deficient mice","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>The humoral immune system influences the development of atherosclerosis, but the contributions of specific memory B cell subsets and IgG isotypes are poorly understood. We assessed the relationship between atherosclerosis and age-associated B cells (ABCs), a T-bet–expressing memory B cell subset that is enriched for IgG2c production and implicated in humoral autoimmunity. We found increased numbers of splenic CD11c+ ABCs in 6-mo-old, chow-fed Apoe−/− mice versus C57BL/6 control mice, which were exacerbated by high-fat diet. Deletion of T-bet in the B lineage in high-fat diet–fed Apoe−/− mice reduced aortic lesion area, and this correlated with decreased splenic CD11c+ B cells and reduced serum oxidized low-density lipoprotein–specific IgG2c. Our findings suggest that T-bet–expressing B cells are atherogenic agents in the Apoe−/− model and indicate that interventions to inhibit a T-bet–driven humoral response may improve atherosclerotic disease.</jats:p>","journal":"The Journal of Immunology","year":2025,"id":639178,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1660533,"name":"Katalin Karolyi","orcid":"0000-0003-0638-5370","position":1,"is_corresponding":false},{"id":509825,"name":"James Monslow","orcid":"0000-0002-6775-489X","position":2,"is_corresponding":false},{"id":1147300,"name":"Debra Cromley","orcid":null,"position":3,"is_corresponding":false},{"id":650935,"name":"Daniel J Rader","orcid":"0000-0002-6907-9031","position":4,"is_corresponding":false},{"id":103971,"name":"Ellen Puré","orcid":"0000-0003-2107-3711","position":5,"is_corresponding":false},{"id":244598,"name":"Michael P. Cancro","orcid":"0000-0002-8659-3227","position":6,"is_corresponding":false},{"id":244594,"name":"James J. Knox","orcid":"0000-0002-3523-0661","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"T-bet–expressing B cells promote atherosclerosis in apolipoprotein E–deficient mice","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>The humoral immune system influences the development of atherosclerosis, but the contributions of specific memory B cell subsets and IgG isotypes are poorly understood. We assessed the relationship between atherosclerosis and age-associated B cells (ABCs), a T-bet–expressing memory B cell subset that is enriched for IgG2c production and implicated in humoral autoimmunity. We found increased numbers of splenic CD11c+ ABCs in 6-mo-old, chow-fed Apoe−/− mice versus C57BL/6 control mice, which were exacerbated by high-fat diet. Deletion of T-bet in the B lineage in high-fat diet–fed Apoe−/− mice reduced aortic lesion area, and this correlated with decreased splenic CD11c+ B cells and reduced serum oxidized low-density lipoprotein–specific IgG2c. Our findings suggest that T-bet–expressing B cells are atherogenic agents in the Apoe−/− model and indicate that interventions to inhibit a T-bet–driven humoral response may improve atherosclerotic disease.</jats:p>","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40073097","pmcid":"PMC11952879","openalex_id":"https://openalex.org/W4408142458","authors":[],"funders":[{"funder_name":"National Heart, Lung, and Blood Institute","grant_id":"T32 HL07954","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"T32 AI055428","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"T32 HL007954","title":null}],"total_grants":3,"fwci":1.9337,"citation_percentile":0.85339184,"influential_citations":0,"citation_trend":[{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"bronze","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://academic.oup.com/jimmunol/advance-article-pdf/doi/10.1093/jimmun/vkae027/62178969/vkae027.pdf","host_type":"journal"},{"url":"https://academic.oup.com/jimmunol/advance-article-pdf/doi/10.1093/jimmun/vkae027/62178969/vkae027.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/jimmunol/article-pdf/214/3/317/62178969/vkae027.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/jimmun/vkae027","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40073097","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11952879","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11952879/","host_type":"repository"}],"fields_of_study":["Atherosclerosis and Cardiovascular Diseases","T-cell and B-cell Immunology","Immune Cell Function and Interaction"],"mesh_terms":["Mice, Knockout, ApoE","T-bet Transcription Factor","Animals","Apolipoproteins E","B-Lymphocytes","Disease Models, Animal","Immunoglobulin G","Lipoproteins, LDL","Mice, Inbred C57BL","B-Lymphocyte Subsets","Mice, Knockout","T-Box Domain Proteins","Atherosclerosis","Mice","Immunity, Humoral","Diet, High-Fat"],"keywords":["Apolipoprotein B","Apolipoprotein E","Molecular biology","Medicine","Biology","Internal medicine","Cholesterol","Disease","Atherosclerosis","B lymphocytes","Autoantibody","T-bet","Age-associated B Cells"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T22:48:10.239047Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}