{"doi":"10.1093/jbi/wbag006","title":"Imaging Features and Risk Factors Associated with Locoregional Recurrence of Breast Cancer: Insights for Imaging and Clinical Practice","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Women with a personal history of breast cancer (PHBC) remain at risk for ipsilateral breast tumor recurrence or a second primary tumor, with a cumulative incidence of 14.3% and reported annual risk of approximately 1–2%. Post-treatment changes can obscure imaging findings, making early recognition of recurrence a challenging, but critical skill for breast radiologists. Detection of early breast cancer recurrence, before it becomes symptomatic, is linked to improved survival, highlighting the need for multimodality surveillance imaging. This review summarizes key prognostic factors that influence recurrence risk and should inform imaging interpretation. Incorporating these prognostic factors into practice can aid imaging interpretation by heightening the attention to subtle changes that may reflect early recurrence. Illustrative cases are used to demonstrate the imaging spectrum of locoregional recurrence in post-lumpectomy and post-mastectomy patients. Recurrences often resemble the imaging features of the primary tumor but may also present subtly. The distinction between recurrence and benign post-treatment change is emphasized, with attention to imaging findings that warrant further evaluation. Finally, emerging evidence-based recommendations for risk-adapted surveillance incorporating tumor biology, receptor status, and stage are reviewed to support early detection and improved outcomes</jats:p>","journal":"Journal of Breast Imaging","year":2026,"id":626088,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1619451,"name":"Fara Shikoh","orcid":null,"position":1,"is_corresponding":false},{"id":1619452,"name":"Haley P Letter","orcid":null,"position":2,"is_corresponding":false},{"id":664516,"name":"Santo Maimone","orcid":"0000-0002-3115-0090","position":3,"is_corresponding":false},{"id":1619450,"name":"Aurela Clark","orcid":"0000-0003-2833-2149","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Imaging Features and Risk Factors Associated with Locoregional Recurrence of Breast Cancer: Insights for Imaging and Clinical Practice","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Women with a personal history of breast cancer (PHBC) remain at risk for ipsilateral breast tumor recurrence or a second primary tumor, with a cumulative incidence of 14.3% and reported annual risk of approximately 1–2%. Post-treatment changes can obscure imaging findings, making early recognition of recurrence a challenging, but critical skill for breast radiologists. Detection of early breast cancer recurrence, before it becomes symptomatic, is linked to improved survival, highlighting the need for multimodality surveillance imaging. This review summarizes key prognostic factors that influence recurrence risk and should inform imaging interpretation. Incorporating these prognostic factors into practice can aid imaging interpretation by heightening the attention to subtle changes that may reflect early recurrence. Illustrative cases are used to demonstrate the imaging spectrum of locoregional recurrence in post-lumpectomy and post-mastectomy patients. Recurrences often resemble the imaging features of the primary tumor but may also present subtly. The distinction between recurrence and benign post-treatment change is emphasized, with attention to imaging findings that warrant further evaluation. Finally, emerging evidence-based recommendations for risk-adapted surveillance incorporating tumor biology, receptor status, and stage are reviewed to support early detection and improved outcomes</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42161482","pmcid":null,"openalex_id":"https://openalex.org/W7162014018","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.59050208,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://academic.oup.com/jbi/article-pdf/8/3/318/68137720/wbag006.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/jbi/wbag006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42161482","host_type":"repository"}],"fields_of_study":["Breast Cancer Treatment Studies","Breast Lesions and Carcinomas","Medical Imaging Techniques and Applications"],"mesh_terms":["Breast","Breast Neoplasms","Female","Humans","Mammography","Neoplasm Recurrence, Local","Prognosis","Risk Factors"],"keywords":["Breast cancer","Clinical Practice","Breast imaging","Medical imaging","Incidence (geometry)","Stage (stratigraphy)","Mammography","Cancer","risk factors","Unilateral","Locoregional","Breast Cancer Recurrence","Tumor Characteristics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T12:23:03.442011Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}