{"doi":"10.1093/jbi/wbaf042","title":"Follow-up Recommendations for Young, Average Risk Women With BI-RADS 3 Masses","abstract":"OBJECTIVE: To determine the outcome and malignancy rate of BI-RADS 3 masses during follow-up at 6, 12, and 24 months. METHODS: This retrospective cohort study identified female patients <35 years of age with an oval, parallel, circumscribed mass assigned a BI-RADS 3 assessment on US from January 2014 to December 2021. Inclusion criteria were average risk women with a 6-month follow-up US and either (1) ≥18 months of follow-up imaging or (2) surgical excision/biopsy. Initial US lesion characteristics; follow-up BI-RADS assessments at 6, 12, 18, and 24 months; and pathology results were recorded. RESULTS: There were 662 patients with a BI-RADS 3 mass on US, of whom 191 were patients (mean age 26.4 ± 6.0 years) with 228 lesions (mean size 1.6 ± 0.7 cm) who met inclusion criteria. Most lesions exhibited either 2-year stability (56%, 128/228) or decreased in size/resolved (8%, 18/228). In all, 31% (71/228) of lesions were biopsied, most commonly because of increasing size (93%, 66/71). Most enlarging lesions underwent biopsy at the 6-month follow-up (68%, 45/66). All 71 lesions recommended for biopsy were fibroadenomas with a positive predictive value and malignancy rate of 0%. No phyllodes tumors were detected. CONCLUSION: There were no cancers among young female patients with probably benign (BI-RADS 3) masses on US. A single 6-month imaging follow-up and then ongoing clinical surveillance may be sufficient in assessing probably benign masses in young women aged <35 years.","journal":"Journal of Breast Imaging","year":2025,"id":580861,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6647,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":905775,"name":"Derek L. Nguyen","orcid":"0000-0001-9991-5611","position":1,"is_corresponding":false},{"id":506497,"name":"Lars J. Grimm","orcid":"0000-0002-3865-3352","position":2,"is_corresponding":false},{"id":1310346,"name":"Sujata V. Ghate","orcid":"0000-0003-1889-982X","position":3,"is_corresponding":false},{"id":35817,"name":"Katie Shpanskaya","orcid":"0000-0003-2741-4046","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:58:43.046112Z","pmid":"41217444","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}