{"doi":"10.1093/jbcr/iraf203","title":"Enhanced Burn Wound Healing and Conversion Prevention Through Inhibition of High Mobility Group Box 1 in a Scald Burn Rat Model","abstract":"Severe burns trigger hyperinflammatory and hypermetabolic responses, leading to systemic organ damage. High mobility group box 1 (HMGB1) is an inflammatory peptide released from injured sites. This study investigated wound progression in scald burn rats treated with anti-HMGB1 antibody (Ab). Male Sprague-Dawley rats were divided into sham burn (n = 5), burn with vehicle treatment (n = 8), and burn with anti-HMGB1 Ab treatment (n = 8). After 30% total body surface area burns, rats were treated with chicken IgY (burn/vehicle group) or anti-HMGB1 Ab (burn/treatment group). Skin samples were collected at 3 and 14 days after burn for histological analysis of wound composition and healing. ANOVA and post hoc Tukey tests were used for statistical analysis. Anti-HMGB1 Ab improved healing, increasing epithelial thickness on day 14 compared to sham (58 μm ± 22 μm vs 21 μm ± 3 μm; P < .01) and dermal thickness over vehicle (1.7 mm ± 0.23 mm vs 1.4 mm ± 0.25 mm; P < .05). Panniculus carnosus muscle loss was lower in the anti-HMGB1 Ab-treated group than vehicle group (-6.4% ± 1.5% vs -70.9% ± 25%; P = .01). High mobility group box 1 expression decreased in epithelium on day 14 (17.15% ± 11.94% vs 60.83% ± 5.28%; P = .02) and dermal inflammation decreased significantly on day 3 (0.45% ± 0.10% vs 4.05% ± 0.49%; P < .0001). Reducing circulating HMGB1 levels decreases burn wound conversion with improved wound healing.","journal":"Journal of Burn Care & Research","year":2025,"id":547947,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1441149,"name":"Allison M Wyrick","orcid":null,"position":1,"is_corresponding":false},{"id":473501,"name":"Amina El Ayadi","orcid":"0000-0002-3657-0633","position":2,"is_corresponding":false},{"id":542288,"name":"Steven E. Wolf","orcid":"0000-0003-2972-3440","position":3,"is_corresponding":false},{"id":364589,"name":"Nisha Garg","orcid":"0000-0002-3453-2369","position":4,"is_corresponding":false},{"id":905250,"name":"Juquan Song","orcid":"0000-0002-9371-9078","position":5,"is_corresponding":false},{"id":1440704,"name":"S. Lee","orcid":"0009-0001-3420-6010","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:53:53.962932Z","pmid":"41134205","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}